The incidences of anogenital HPV-related cancers in women are on the rise; this is especially true for anal cancer. Medical societies are now beginning to recommend anal cancer screening in certain high-risk populations, including high-risk women with a history of genital dysplasia. The aim of this study is to investigate national anogenital HPV cancer trends as well as the role of demographics, deprivation, and ethnicity on anogenital cancer incidence in England, in an attempt to better understand this cohort of women which is increasingly affected by anogenital HPV-related disease. Demographic data from the Clinical Outcomes and Services Dataset (COSD) were extracted for all patients diagnosed with anal, cervical, vulval and vaginal cancer in England between 2014 and 2020. Outcomes included age, ethnicity, deprivation status and staging. An age over 55 years, non-white ethnicity and high deprivation are significant risk factors for late cancer staging, as per logistic regression. In 2019, the incidences of anal and vulval cancer in white women aged 55–74 years surpassed that of cervical cancer. More needs to be done to educate women on HPV-related disease and their lifetime risk of these conditions.
女性肛门生殖器人乳头瘤病毒（HPV）相关癌症的发病率正在上升，肛门癌尤为明显。目前，医学界开始建议对某些高风险人群进行肛门癌筛查，包括有生殖器发育不良病史的高风险女性。本研究旨在调查英国全国范围内肛门生殖器HPV相关癌症的趋势，以及人口统计学特征、社会经济剥夺状况和种族对肛门生殖器癌症发病率的影响，以更好地理解这一日益受到肛门生殖器HPV相关疾病影响的女性群体。研究提取了2014年至2020年间英格兰所有被诊断为肛门癌、宫颈癌、外阴癌和阴道癌患者的临床结局与服务数据集（COSD）中的人口统计学数据，包括年龄、种族、剥夺状况和癌症分期。逻辑回归分析显示，年龄超过55岁、非白人族裔以及高度社会经济剥夺是癌症晚期分期的显著风险因素。2019年，55至74岁白人女性的肛门癌和外阴癌发病率已超过宫颈癌。未来需加强针对HPV相关疾病及其终身风险的女性健康教育。
Anogenital HPV-Related Cancers in Women: Investigating Trends and Sociodemographic Risk Factors
肿瘤(癌症)患者之家