This study addresses the critical need for the accurate diagnosis and management of intraductal papillary mucinous neoplasms (IPMNs), which are pancreatic cystic neoplasm types holding a substantial potential for malignancy. It evaluates the diagnostic effectiveness of the Fukuoka consensus guidelines and the European evidence-based guidelines in detecting high-grade dysplasia/invasive carcinoma in IPMNs, utilizing a retrospective analysis of 113 patients from two European medical centers. The methods include a comparative analysis of clinical, radiological, and endoscopic ultrasonography data, alongside an assessment of guideline-driven diagnostic performance. The results demonstrate that both guidelines offer similar accuracy in identifying severe disease stages in IPMNs, with certain clinical markers—such as jaundice, solid mass presence, and an increase in CA 19-9 levels—being pivotal in predicting the need for surgical intervention. This study concludes that while both guidelines provide valuable frameworks for IPMN management, there is an inherent need for further research to refine these protocols and improve patient-specific treatment strategies. This research contributes to the ongoing discourse on optimizing diagnostic and treatment paradigms for pancreatic cystic neoplasms, aiming to enhance clinical outcomes and patient care in this challenging medical field.
本研究针对胰腺导管内乳头状黏液性肿瘤（IPMN）这一具有显著恶性潜能的胰腺囊性肿瘤类型，探讨其精确诊断与临床管理的迫切需求。通过对欧洲两家医疗中心113例患者的回顾性分析，评估了《福冈共识指南》与《欧洲循证指南》在识别IPMN高级别异型增生/浸润性癌方面的诊断效能。研究方法包括对临床、影像学及超声内镜数据的比较分析，并对指南驱动的诊断性能进行评估。结果显示，两项指南在识别IPMN严重病变阶段方面具有相近的准确性，其中黄疸、实性肿块存在及CA19-9水平升高等临床标志物对预测手术干预需求具有关键作用。本研究结论指出，尽管两项指南为IPMN管理提供了有价值的框架，但仍需进一步研究以完善这些诊疗方案并优化个体化治疗策略。此项研究有助于推动胰腺囊性肿瘤诊断与治疗模式的优化讨论，旨在提升这一临床挑战领域的诊疗效果与患者照护水平。
肿瘤(癌症)患者之家