This review article investigates the utilization of MRS in the setting of cervical cancer. A variety of different techniques have been used in this space including single-voxel techniques such as point-resolved spectroscopy (PRESS) and stimulated echo acquisition mode spectroscopy (STEAM). Furthermore, the experimental parameters for these acquisitions including field strength, repetition times (TR), and echo times (TE) vary greatly. This study critically examines eleven MRS studies that focus on cervical cancer. Out of the eleven studies, ten studies utilized PRESS acquisition, while the remaining study used STEAM acquisition. These studies generally showed that the choline signal is altered in cervical cancer (4/11 studies), the lipid signal is generally increased in cervical cancer or the lipid distribution is changed (5/11 studies), and that diffusion-weighted imaging (DWI) can quantitatively detect lower apparent diffusion coefficient (ADC) values in cervical cancer (2/11 studies). Two studies also investigated the role of MRS for monitoring treatment response and demonstrated mixed results regarding choline signal, and one of these studies showed increased lipid signal for non-responders. There are several new MRS technologies that have yet to be implemented for cervical cancer including advanced spectroscopic imaging and artificial intelligence, and those technologies are also discussed in the article.
本综述探讨了磁共振波谱（MRS）在宫颈癌领域的应用。该领域已采用多种技术，包括单体素技术如点分辨波谱（PRESS）和受激回波采集模式波谱（STEAM）。此外，相关采集实验参数（如场强、重复时间与回波时间）存在显著差异。本文系统评析了十一项聚焦宫颈癌的MRS研究，其中十项采用PRESS采集技术，一项采用STEAM技术。综合分析表明：多数研究提示胆碱信号在宫颈癌中存在异常改变（4/11研究），脂质信号普遍增强或分布模式发生变化（5/11研究），扩散加权成像可定量检测宫颈癌中表现扩散系数降低现象（2/11研究）。两项研究探索了MRS在疗效监测中的作用，其中关于胆碱信号变化的结果存在差异，且其中一项研究显示治疗无应答者的脂质信号增强。文章同时讨论了尚未应用于宫颈癌研究的新型MRS技术，包括先进波谱成像与人工智能技术。
Magnetic Resonance Spectroscopy for Cervical Cancer: Review and Potential Prognostic Applications
肿瘤(癌症)患者之家