French Guiana is a French Overseas territory with singular features: it has a high prevalence of HIV and HTLV-1, its population is ethnically mixed, with widespread poverty, and up to 20% of the population lives in geographic isolation. In this context, we used registry data to estimate incidence and mortality due to hematological malignancies and to compare them with France and tropical Latin America. ICD codes C90 and C88 were compiled between 2005 and 2014. The direct standardization of age structure was performed using the world population. Survival analysis was performed, and Kaplan–Meier curves were drawn. The overall standardized incidence rate was 32.9 per 100,000 male years and 24.5 per 100,000 female years. Between 2005 and 2009, the standardized incidence rate was 29.6 per 100,000 among men and 23.6 per 100,000 among women, and between 2010 and 2014, it was 35.6 per 100,000 among men and 25.2 per 100,000 among women. Multiple myeloma/plasmocytoma and mature t/NK cell lymphomas, notably adult t-cell lymphoma/leukemia due to HTLV-1 infection, were the two most common hematologic malignancies and causes of death. Non-Hodgkin’s lymphoma incidence estimates were greater than global estimates. After adjusting for age, sex, and type of malignancy, people born in a foreign country independently had a poorer case-fatality rate, presumably reflecting difficulties in accessing care. The epidemiology of hematological malignancies in French Guiana has features that distinguish it from mainland France or from Latin America. The incidence of multiple myeloma and adult t-cell lymphoma/leukemia was significantly greater in French Guiana than in France or other Latin American countries.
法属圭亚那作为法国海外领地具有独特特征：该地区HIV和HTLV-1感染率居高不下，人口种族构成复杂，普遍存在贫困现象，且高达20%的居民处于地理隔绝状态。在此背景下，本研究利用登记数据评估了血液系统恶性肿瘤的发病率和死亡率，并与法国及热带拉丁美洲地区进行比较。研究汇总了2005年至2014年间国际疾病分类编码C90和C88的病例数据，采用世界标准人口结构进行直接年龄标准化，执行生存分析并绘制卡普兰-迈耶曲线。结果显示：男性总体标化发病率为32.9/10万人年，女性为24.5/10万人年。2005-2009年间男性标化发病率为29.6/10万人年，女性为23.6/10万人年；2010-2014年间男性升至35.6/10万人年，女性为25.2/10万人年。多发性骨髓瘤/浆细胞瘤以及成熟T/NK细胞淋巴瘤（特别是HTLV-1感染相关的成人T细胞淋巴瘤/白血病）成为最常见的血液系统恶性肿瘤及主要致死原因。非霍奇金淋巴瘤的发病率估值高于全球平均水平。经年龄、性别和恶性肿瘤类型校正后，外国出生患者的独立病死率显著更高，这可能反映了医疗可及性障碍。法属圭亚那血液系统恶性肿瘤的流行病学特征既不同于法国本土，也有别于拉丁美洲地区，其多发性骨髓瘤和成人T细胞淋巴瘤/白血病的发病率显著高于法国及其他拉丁美洲国家。
The Epidemiological Particularities of Malignant Hemopathies in French Guiana: 2005–2014
肿瘤(癌症)患者之家