Tumors that spontaneously shrink from unknown causes in tumor regression, and that return to normal cells in tumor reversion, are phenomena with the potential to contribute new knowledge and novel therapies for cancer patient survival. Tumorigenesis is associated with dysregulated phosphate metabolism and an increased transport of phosphate into tumor cells, potentially mediated by phosphate overload from excessive dietary phosphate intake, a significant problem in Western societies. This paper proposes that reduced dietary phosphate overload and reregulated phosphate metabolism may reverse an imbalance of kinases and phosphatases in cell signaling and cellular proliferation, thereby activating autophagy in tumor regression and reversion. Dietary phosphate can also be reduced by sickness-associated anorexia, fasting-mimicking diets, and other diets low in phosphate, all of which have been associated with tumor regression. Tumor reversion has also been demonstrated by transplanting cancer cells into a healthy microenvironment, plausibly associated with normal cellular phosphate concentrations. Evidence also suggests that the sequestration and containment of excessive phosphate within encapsulated tumors is protective in cancer patients, preventing the release of potentially lethal amounts of phosphate into the general circulation. Reducing dietary phosphate overload has the potential to provide a novel, safe, and effective reversion therapy for cancer patients, and further research is warranted.
肿瘤因未知原因自发缩小的消退现象，以及肿瘤细胞逆转为正常细胞的逆转现象，是具有为癌症患者生存贡献新知识和新疗法潜力的重要生物学事件。肿瘤发生与磷酸盐代谢失调及磷酸盐向肿瘤细胞的转运增加相关，这可能由膳食磷酸盐摄入过量导致的磷酸盐超载所介导——这在西方社会已成为显著问题。本文提出，减少膳食磷酸盐超载并重新调节磷酸盐代谢，可能逆转细胞信号传导和细胞增殖过程中激酶与磷酸酶的失衡状态，从而在肿瘤消退和逆转过程中激活自噬机制。疾病相关性厌食、模拟禁食饮食及其他低磷酸盐饮食均可降低膳食磷酸盐摄入，这些方式均被证实与肿瘤消退相关。将癌细胞移植至健康微环境亦可实现肿瘤逆转，这可能与正常细胞磷酸盐浓度环境有关。研究证据还表明，将过量磷酸盐隔离包裹在肿瘤囊内对癌症患者具有保护作用，可防止致死量磷酸盐释放进入全身循环。降低膳食磷酸盐超载有望为癌症患者提供一种新型、安全、有效的逆转疗法，值得进一步深入研究。
Spontaneous Tumor Regression and Reversion: Insights and Associations with Reduced Dietary Phosphate
肿瘤(癌症)患者之家