Endometrial cancer is one of the most common malignant tumours in women. The development of this tumour is associated with several genetic disorders, many of which are still unknown. One type of RNA molecules currently being intensively studied in many types of cancer are long non-coding RNAs (lncRNAs). LncRNA-coding genes occupy a large fraction of the human genome. LncRNAs regulate many aspects of cell development, metabolism, and other physiological processes. Diverse types of lncRNA can function as a tumour suppressor or an oncogene that can alter migration, invasion, cell proliferation, apoptosis, and immune system response. Recent studies suggest that selected lncRNAs are important in an endometrial cancer course. Our article describes over 70 lncRNAs involved in the development of endometrial cancer, which were studied via in vivo and in vitro research. It was proved that lncRNAs could both promote and inhibit the development of endometrial cancer. In the future, lncRNAs may become an important therapeutic target. The aim of this study is to review the role of lncRNAs in the development of carcinoma of uterine body.
子宫内膜癌是女性最常见的恶性肿瘤之一。该肿瘤的发生与多种遗传异常相关，其中许多机制尚未明确。长链非编码RNA（lncRNAs）作为当前多种癌症研究的热点分子，其编码基因占据人类基因组的很大比例。lncRNAs参与调控细胞发育、代谢及其他生理过程的多个层面，不同类型lncRNAs可作为肿瘤抑制因子或癌基因，影响肿瘤细胞的迁移、侵袭、增殖、凋亡及免疫应答。最新研究表明特定lncRNAs在子宫内膜癌病程中具有重要作用。本文通过体内外实验研究了70余种参与子宫内膜癌发生发展的lncRNAs，证实其既能促进也能抑制子宫内膜癌进展。未来lncRNAs可能成为重要的治疗靶点。本研究旨在系统阐述lncRNAs在子宫体癌发生发展中的作用机制。
The Promotive and Inhibitory Role of Long Non-Coding RNAs in Endometrial Cancer Course—A Review
肿瘤(癌症)患者之家