(1) Background: To compare oncologic outcomes of South Asian (SA) patients treated for oral squamous cell carcinoma (OSCC) to the general population. (2) Methods: Adult patients who underwent surgical resection of OSCC +/− adjuvant treatment between 2009 and 2022 (N = 697) at a regional cancer centre in Canada were included. SA patients, identified using a validated method, were compared to non-SA patients. Kaplan–Meier methods were used to compare the primary outcomes, disease-specific survival (DSS) and recurrence-free survival (RFS) across baseline univariate characteristics, including betel nut consumption. Median follow-up time was 36.4 months. Cox proportional hazard models were used to identify independent predictors of survival with significance set atp< 0.05. (3) Results: SA patients (9% of cohort, N = 64) were significantly younger and had lower rates of smoking and alcohol consumption compared to non-SA patients (p< 0.05). SA patients had a two-fold higher risk of recurrence and significantly worse disease-specific survival, even after adjusting for stage and high-risk features [RFS: HR 2.01 (1.28–3.14), DSS: HR 1.79 (1.12–2.88)]. The consumption of betel nut was not associated with outcomes. (4) Conclusions: SA patients had significantly worse oncologic outcomes, even after controlling for known predictors of poor prognosis. These findings are novel and can inform personalized treatment decisions and influence public health policies when managing patients with different ethnic backgrounds.
（1）背景：本研究旨在比较南亚裔（SA）口腔鳞状细胞癌（OSCC）患者与普通人群的肿瘤学预后差异。（2）方法：纳入2009年至2022年间在加拿大某区域癌症中心接受OSCC手术切除±辅助治疗的成年患者（N=697）。通过验证方法识别南亚裔患者，并与非南亚裔患者进行对比。采用Kaplan-Meier法比较主要结局指标（疾病特异性生存期[DSS]和无复发生存期[RFS]）在不同基线单变量特征（包括槟榔食用情况）下的差异。中位随访时间为36.4个月。使用Cox比例风险模型识别生存的独立预测因素，显著性设定为p<0.05。（3）结果：南亚裔患者（占队列9%，N=64）年龄显著更轻，吸烟与饮酒率低于非南亚裔患者（p<0.05）。即使在调整分期和高危特征后，南亚裔患者的复发风险仍高出两倍，疾病特异性生存期显著更差[RFS：HR 2.01（1.28-3.14）；DSS：HR 1.79（1.12-2.88）]。槟榔食用与预后无显著关联。（4）结论：即使在控制已知不良预后因素后，南亚裔患者仍表现出显著更差的肿瘤学结局。该发现具有创新性，可为不同族裔背景患者的个体化治疗决策提供依据，并对公共卫生政策制定产生影响。
The Association of Ethnicity and Oncologic Outcomes for Oral Cavity Squamous Cell Carcinoma (OSCC)
肿瘤(癌症)患者之家