Background and aims: This paper aims to study an alternative solution to hormonal replacement therapy in specific groups of patients who underwent thyroidectomy during childhood or adulthood. After cryopreservation, thyroid autotransplantation could be an alternative solution which would allow us to use the ability of the thyroid tissue of producing hormones according to the physiological needs of the body. Materials and methods: A feasibility study about the effects of the most modern cryopreservation techniques on the structural and functional integrity of the follicular cells of the thyroid tissue has been carried out. Patients who could benefit from the treatment have been found for both autotransplant techniques. Additionally, a literature review has been conducted. Results: The histological analysis has shown that cryopreservation does not alter the original architecture, and the culture examination that cell viability is successfully preserved. Moreover, both thyroid autotransplantation studies on animals and those on humans that were found in the literature have shown good results regarding the viability and functionality of the transplant. Conclusions: The viability of cryopreserved thyroid tissue found in this study is encouraging. Further studies to evaluate the levels of FT3, FT4 and thyroglobulin in thyroid tissue after cryopreservation are needed to verify that the secretory properties of the thyrocytes have been maintained intact. Furthermore, autotransplanted cases found in the literature do not have a long-term follow-up.
背景与目的：本研究旨在探索针对儿童期或成年期接受甲状腺切除术特定患者群体的激素替代疗法替代方案。甲状腺组织经冷冻保存后实施自体移植，可利用甲状腺组织根据机体生理需求分泌激素的能力，成为潜在的替代治疗方案。材料与方法：本研究通过可行性分析，评估现代冷冻保存技术对甲状腺滤泡细胞结构与功能完整性的影响。针对两种自体移植技术，筛选出可能受益于该疗法的患者群体，并进行了系统性文献综述。结果：组织学分析显示冷冻保存未改变组织原始结构，细胞培养检测证实细胞活性得到有效保持。文献中动物与人类甲状腺自体移植研究均显示移植体具有良好的活性与功能状态。结论：本研究发现冷冻保存后甲状腺组织具有良好活性，结果令人鼓舞。未来需进一步检测冷冻保存后甲状腺组织中游离三碘甲状腺原氨酸、游离甲状腺素及甲状腺球蛋白水平，以验证甲状腺细胞分泌功能是否保持完整。此外，现有文献报道的自体移植病例均缺乏长期随访数据。
肿瘤(癌症)患者之家