文章：

肺癌家族史与肺癌发病风险关联性分析：基于韩国基因组与流行病学研究数据

The Association between Family History of Lung Cancer and Development of Lung Cancer: Analysis from the KoGES Data in Korea

原文发布日期：30 May 2024

DOI: 10.3390/cancers16112063

类型: Article

开放获取: 是

英文摘要：

Comprehensive analyses of the association between a family history of lung cancer and lung cancer risk are limited, especially in the Korean population. We used baseline data from the Korean Genome and Epidemiology Study, conducted between 2001 and 2013. This study enrolled 198,980 individuals. Lung cancer diagnoses and family histories were determined using questionnaires. Multivariable logistic regression analysis was performed to evaluate the effect of family history on the risk of lung cancer. Of 198,980 individuals, 6296 (3.2%) and 140 (0.1%) had a family history of lung cancer and lung cancer, respectively. Individuals with a family history of lung cancer in first-degree relatives (FDRs) had a higher risk of lung cancer development than those without (adjusted odds ratio [aOR] = 2.28, 95% confidence interval [CI] = 1.11–4.66). This was more pronounced in young individuals (<60 years) who had affected relatives diagnosed with lung cancer before the age of 60 years (aOR = 3.77, 95% CI = 1.19–11.88). In subgroup analyses, this association was more evident in women, never smokers, and young individuals. A family history of lung cancer, especially in FDRs, is a significant risk factor for lung cancer development in Korea.

摘要翻译： 

关于肺癌家族史与肺癌风险关联的综合分析研究尚不充分，尤其在韩国人群中更为有限。本研究基于2001年至2013年间开展的韩国基因组与流行病学研究基线数据，共纳入198,980名参与者。通过问卷调查确定肺癌诊断及家族史信息，并采用多变量逻辑回归分析评估家族史对肺癌风险的影响。在198,980名研究对象中，分别有6296人（3.2%）具有肺癌家族史，140人（0.1%）确诊肺癌。与无肺癌家族史者相比，一级亲属有肺癌家族史的个体罹患肺癌风险显著升高（校正比值比[aOR] = 2.28，95%置信区间[CI] = 1.11–4.66）。这种关联在年轻群体（<60岁）中尤为突出，若其亲属在60岁前确诊肺癌，则患病风险进一步增加（aOR = 3.77，95% CI = 1.19–11.88）。亚组分析显示，该关联在女性、非吸烟者及年轻个体中更为显著。研究表明，在韩国人群中，肺癌家族史（尤其是一级亲属）是肺癌发生的重要风险因素。

原文链接：

The Association between Family History of Lung Cancer and Development of Lung Cancer: Analysis from the KoGES Data in Korea