文章：

SARS-CoV-2（COVID-19）大流行对波兰国家转诊中心葡萄膜黑色素瘤特征及治疗管理的影响

Impact of the SARS-CoV-2 (COVID-19) Pandemic on Characteristics and Management of Uveal Melanoma in the National Referral Center in Poland

原文发布日期：29 May 2024

DOI: 10.3390/cancers16112061

类型: Article

开放获取: 是

英文摘要：

(1) Background: to analyze the impact of the COVID-19 pandemic on the characteristics and management of uveal melanoma (UM) in the National Referral Center in Poland. (2) Materials and Methods: the retrospective analysis of 1336 patients who were newly diagnosed with UM at the Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University Collegium Medicum Krakow, Poland between 1 January 2018 and 31 December 2021. The demographic and clinical data were compiled, including localization, size, and treatment methods of tumors. (3) Results: In total, 728 patients with UM were included before the COVID-19 pandemic, in the years 2018–2019, and 608 were included during the COVID-19 pandemic, in the years 2020–2021. Fixed-base dynamics indicators for the incidence of uveal melanoma (base year 2018) in the National Referral Center in Poland were 80.22% and 86.81% in the years 2020 and 2021, respectively. UMs were statistically significantly larger and more frequently localized anterior to the equator of the eye globe in the year 2021 than in the year 2018 (Chi-square Pearson testp= 0.0001 andp= 0.0077, respectively). The rate of patients treated with enucleation increased from 15.94% in the year 2018 to 26.90% in the year 2021 (Chi-square Pearson testp= 0.0005). (4) Conclusions: Statistically significant differences were found in the management of uveal melanoma in the National Referral Center in Poland during the COVID-19 pandemic with tumors being larger, more frequently localized anterior to the equator of the eye globe, and more often enucleated.

摘要翻译： 

（1）背景：旨在分析COVID-19大流行对波兰国家转诊中心葡萄膜黑色素瘤（UM）特征及诊疗管理的影响。（2）材料与方法：回顾性分析2018年1月1日至2021年12月31日期间，在波兰克拉科夫雅盖隆大学医学院眼科与眼肿瘤科新确诊的1336例UM患者。收集人口统计学及临床资料，包括肿瘤位置、大小及治疗方法。（3）结果：2018-2019年大流行前共纳入728例UM患者，2020-2021年大流行期间纳入608例。以2018年为基准年，波兰国家转诊中心葡萄膜黑色素瘤发病率的定基动态指标在2020年和2021年分别为80.22%和86.81%。与2018年相比，2021年UM肿瘤体积显著增大（皮尔逊卡方检验p=0.0001），且更常位于眼球赤道前部（p=0.0077）。眼球摘除术治疗率从2018年的15.94%上升至2021年的26.90%（皮尔逊卡方检验p=0.0005）。（4）结论：COVID-19大流行期间，波兰国家转诊中心葡萄膜黑色素瘤的诊疗管理存在统计学显著差异，表现为肿瘤体积更大、赤道前部定位更常见、眼球摘除术实施更频繁。

原文链接：

Impact of the SARS-CoV-2 (COVID-19) Pandemic on Characteristics and Management of Uveal Melanoma in the National Referral Center in Poland