文章：

多标记物联合超声在附件肿块分类中的增强应用价值

Utility of a Multi-Marker Panel with Ultrasound for Enhanced Classification of Adnexal Mass

原文发布日期：28 May 2024

DOI: 10.3390/cancers16112048

类型: Article

开放获取: 是

英文摘要：

Pre-surgical clinical assessment of an adnexal mass typically relies on transvaginal ultrasound for comprehensive morphological assessment, with further support provided by biomarker measurements and clinical evaluation. Whilst effective for masses that are obviously benign or malignant, a large proportion of masses remain sonographically indeterminate at surgical referral. As a consequence, post-surgical diagnoses of benign disease can outnumber malignancies up to 9-fold, while less than 50% of cancer cases receive a primary referral to a gynecological oncology specialist. We recently described a blood biomarker signature (multi-marker panel—MMP) that differentiated patients with benign from malignant ovarian disease with high accuracy. In this study, we have examined the use of the MMP, both individually and in combination with transvaginal ultrasound, as an alternative tool to CA-125 for enhanced decision making in the pre-surgical referral process.

摘要翻译： 

附件包块的术前临床评估通常依赖于经阴道超声进行全面的形态学评估，并辅以生物标志物测量和临床评估。虽然对于明显良性或恶性的包块有效，但在手术转诊时，仍有很大一部分包块在超声检查中无法确定性质。因此，术后诊断为良性的病例数量可能高达恶性肿瘤的9倍，而不到50%的癌症病例被首次转诊至妇科肿瘤专科医生。我们最近描述了一种血液生物标志物特征（多标志物组合—MMP），能够以高准确度区分良性与恶性卵巢疾病患者。在本研究中，我们探讨了MMP单独使用以及与经阴道超声结合使用，作为CA-125的替代工具，以增强术前转诊过程中的决策能力。

原文链接：

Utility of a Multi-Marker Panel with Ultrasound for Enhanced Classification of Adnexal Mass