Epidemiological results on the link between chronic stress and cancer initiation have been inconsistent. This study examined the relation between chronic biological stress, indicated as hair cortisol (HairF) and hair cortisone (HairE), and cancer incidence, adjusting for metabolic syndrome (MetS) components. We analyzed HairF and HairE samples from 6341 participants from the population-based cohort Lifelines in 2014. A linkage with the Dutch Nationwide Pathology Databank (Palga) provided the cancer incidence from 2015 to 2021. The association between dichotomized HairF and log-transformed HairE (LogHairE) and cancer incidence was estimated using Cox regression. MetS components were evaluated as confounders or moderators. Of the 2776 participants with known HairF levels and no cancer history, 238 developed cancer. The HairF level did not predict cancer incidence (HR: 0.993, 95%CI: 0.740–1.333). No confounders or moderators were identified. Among the 4699 participants with known HairE levels and no cancer history, 408 developed cancer. There was no association between LogHairE and cancer incidence (HR: 1.113, 95%CI: 0.738–1.678). When including age as a confounder and gender as a moderator, LogHairE was statistically significantly associated with cancer incidence (HR: 6.403, 95%CI: 1.110–36.92). In a population-based cohort, chronic biological stress, measured by HairE, was associated with cancer incidence, after controlling for age and gender.
关于慢性应激与癌症发生之间关联的流行病学研究结果尚不一致。本研究通过调整代谢综合征（MetS）组分，探讨了以头发皮质醇（HairF）和头发皮质酮（HairE）为指标的慢性生物应激与癌症发病率之间的关系。我们分析了2014年基于人群的队列研究Lifelines中6341名参与者的HairF和HairE样本。通过与荷兰全国病理学数据库（Palga）的关联，获得了2015年至2021年的癌症发病率数据。使用Cox回归评估了二分类HairF与对数转换HairE（LogHairE）与癌症发病率之间的关联，并将MetS组分作为混杂因素或调节因素进行评估。在2776名已知HairF水平且无癌症史的参与者中，有238人罹患癌症。HairF水平未能预测癌症发病率（HR：0.993，95%CI：0.740–1.333），未发现混杂因素或调节因素。在4699名已知HairE水平且无癌症史的参与者中，有408人罹患癌症。LogHairE与癌症发病率之间无显著关联（HR：1.113，95%CI：0.738–1.678）。当将年龄作为混杂因素、性别作为调节因素纳入分析时，LogHairE与癌症发病率呈统计学显著相关（HR：6.403，95%CI：1.110–36.92）。在基于人群的队列中，控制年龄和性别因素后，通过HairE测量的慢性生物应激与癌症发病率相关。
Chronic Stress Related to Cancer Incidence, including the Role of Metabolic Syndrome Components
肿瘤(癌症)患者之家