(1) Background: Myxopapillary ependymoma (MPE) is a rare tumor of the spine, typically slow-growing and low-grade. Optimal management strategies remain unclear due to limited evidence given the low incidence of the disease. (2) Methods: We analyzed data from 1197 patients with spinal MPE from the Surveillance, Epidemiology, and End Results (SEER) database (2000–2020). Patient demographics, treatment modalities, and survival outcomes were examined using statistical analyses. (3) Results: Most patients were White (89.9%) with a median age at diagnosis of 42 years. Surgical resection was performed in 95% of cases. The estimated 10-year overall survival was 91.4%. Younger age (hazard ratio (HR) = 1.09,p< 0.001) and receipt of surgery (HR = 0.43,p= 0.007) were associated with improved survival. Surprisingly, male sex was associated with worse survival (HR = 1.86,p= 0.008) and a younger age at diagnosis compared to females. (4) Conclusions: This study, the largest of its kind, underscores the importance of surgical resection in managing spinal MPE. The unexpected association between male sex and worse survival warrants further investigation into potential sex-specific pathophysiological factors influencing prognosis. Despite limitations, our findings contribute valuable insights for guiding clinical management strategies for spinal MPE.
（1）背景：黏液乳头型室管膜瘤是一种罕见的脊柱肿瘤，通常生长缓慢且恶性程度较低。由于该疾病发病率低、相关证据有限，其最佳治疗策略尚不明确。（2）方法：我们基于美国监测、流行病学和最终结果数据库（2000-2020年）中1197例脊柱黏液乳头型室管膜瘤患者的数据进行分析。通过统计学方法评估患者人口学特征、治疗方案及生存结局。（3）结果：患者以白人为主（89.9%），诊断中位年龄为42岁。95%的病例接受了手术切除。10年总生存率估计值为91.4%。年龄较轻（风险比=1.09，p<0.001）和接受手术治疗（风险比=0.43，p=0.007）与生存改善相关。值得注意的是，男性患者不仅诊断年龄较女性更小，且生存结局更差（风险比=1.86，p=0.008）。（4）结论：作为该领域最大规模的研究，本文证实了手术切除在脊柱黏液乳头型室管膜瘤治疗中的核心地位。男性患者生存率更低的意外发现，提示需要进一步探究影响预后的性别特异性病理生理因素。尽管存在局限性，本研究结果为制定脊柱黏液乳头型室管膜瘤临床管理策略提供了重要依据。
肿瘤(癌症)患者之家