The quality of radiation therapy (RT) treatment plans directly affects the outcomes of clinical trials. KBP solutions have been utilized in RT plan quality assurance (QA). In this study, we evaluated the quality of RT plans for brain and head/neck cancers enrolled in multi-institutional clinical trials utilizing a KBP approach. The evaluation was conducted on 203 glioblastoma (GBM) patients enrolled in NRG-BN001 and 70 nasopharyngeal carcinoma (NPC) patients enrolled in NRG-HN001. For each trial, fifty high-quality photon plans were utilized to build a KBP photon model. A KBP proton model was generated using intensity-modulated proton therapy (IMPT) plans generated on 50 patients originally treated with photon RT. These models were then applied to generate KBP plans for the remaining patients, which were compared against the submitted plans for quality evaluation, including in terms of protocol compliance, target coverage, and organ-at-risk (OAR) doses. RT plans generated by the KBP models were demonstrated to have superior quality compared to the submitted plans. KBP IMPT plans can decrease the variation of proton plan quality and could possibly be used as a tool for developing improved plans in the future. Additionally, the KBP tool proved to be an effective instrument for RT plan QA in multi-center clinical trials.
放射治疗（RT）计划的质量直接影响临床试验的结果。知识型计划（KBP）解决方案已应用于RT计划质量保证（QA）。本研究采用KBP方法评估了参与多中心临床试验的脑部和头颈部癌症患者的RT计划质量。评估对象包括参与NRG-BN001试验的203例胶质母细胞瘤（GBM）患者和参与NRG-HN001试验的70例鼻咽癌（NPC）患者。针对每项试验，我们利用50例高质量光子计划构建了KBP光子模型，并通过50例原接受光子放疗患者的调强质子治疗（IMPT）计划生成了KBP质子模型。随后应用这些模型为其余患者生成KBP计划，并与提交的原始计划进行质量对比评估，包括方案符合性、靶区覆盖度及危及器官（OAR）受照剂量等指标。结果显示，KBP模型生成的RT计划质量优于提交的原始计划。KBP IMPT计划能够减少质子计划质量的差异性，未来或可作为优化治疗计划的工具。此外，KBP工具被证实是多中心临床试验中RT计划质量保证的有效手段。
肿瘤(癌症)患者之家