文章：

前列腺癌雄激素剥夺治疗的代谢反应

Metabolic Response to Androgen Deprivation Therapy of Prostate Cancer

原文发布日期：24 May 2024

DOI: 10.3390/cancers16111991

类型: Article

开放获取: 是

英文摘要：

Prostate cancer (PC) stands as the most frequently diagnosed non-skin cancer and ranks as the second highest cause of cancer-related deaths among men in the United States. For those facing non-metastatic PC necessitating intervention, solely local treatments may not suffice, leading to a possible transition toward systemic therapies, including androgen deprivation therapy (ADT), chemotherapy, and therapies targeting androgen. Yet, these systemic treatments often bring about considerable adverse effects. Additionally, it is observed that overweight men are at a higher risk of developing aggressive forms of PC, advancing to metastatic stages, and succumbing to the disease. Consequently, there is a pressing demand for new treatment options that carry fewer side effects and enhance the current standard treatments, particularly for the majority of American men who are overweight or obese. In this article, we will review the metabolic response to ADT and how lifestyle modulation can mitigate these ADT-associated metabolic responses with a particular focus on the two clinical trials, Carbohydrate and Prostate Study 1 (CAPS1) and Carbohydrate and Prostate Study 2 (CAPS2), which tested the effects of low-carbohydrate diets on the metabolic side effects of ADT and PC progression, respectively. Furthermore, we will summarize the findings of serum metabolomic studies to elucidate the potential mechanisms by which ADT and low-carbohydrate diets can affect the metabolic response to mitigate the metabolic side effects while maximizing therapeutic efficacy.

摘要翻译： 

前列腺癌是美国男性中最常被诊断的非皮肤恶性肿瘤，也是癌症相关死亡的第二大原因。对于需要干预的非转移性前列腺癌患者，仅靠局部治疗可能不足，可能需转向包括雄激素剥夺疗法、化疗及靶向雄激素治疗在内的系统性疗法。然而，这些系统性治疗常伴随显著不良反应。此外，超重男性罹患侵袭性前列腺癌、进展至转移阶段并最终死于该疾病的风险更高。因此，迫切需要开发副作用更少且能增强现有标准治疗方案的新疗法，尤其针对占美国男性多数的超重或肥胖人群。本文将综述雄激素剥夺疗法引发的代谢反应，以及生活方式调整如何减轻这些与雄激素剥夺疗法相关的代谢反应，重点探讨两项临床试验——碳水化合物与前列腺研究1和碳水化合物与前列腺研究2，这两项研究分别测试了低碳水化合物饮食对雄激素剥夺疗法代谢副作用及前列腺癌进展的影响。此外，我们将总结血清代谢组学研究结果，以阐明雄激素剥夺疗法和低碳水化合物饮食影响代谢反应的潜在机制，从而在最大化治疗效果的同时减轻代谢副作用。

原文链接：

Metabolic Response to Androgen Deprivation Therapy of Prostate Cancer