文章：

中央型软骨性骨肿瘤的定量骨SPECT/CT研究：SUVmax与亨斯菲尔德单位放射密度之间的关系

Quantitative Bone SPECT/CT of Central Cartilaginous Bone Tumors: Relationship between SUVmax and Radiodensity in Hounsfield Unit

原文发布日期：22 May 2024

DOI: 10.3390/cancers16111968

类型: Article

开放获取: 是

英文摘要：

(1) Background: it is challenging to determine the accurate grades of cartilaginous bone tumors. Using bone single photon emission computed tomography (SPECT)/computed tomography (CT), maximum standardized uptake value (SUVmax) was found to be significantly associated with different grades of cartilaginous bone tumor. The inquiry focused on the effect of the tumor matrix on SUVmax. (2) Methods: a total of 65 patients from 2017 to 2022 with central cartilaginous bone tumors, including enchondromas and low-to-intermediate grade chondrosarcomas, who had undergone bone SPECT/CT were retrospectively enrolled. The SUVmax was recorded and any aggressive CT findings of cartilaginous bone tumor and Hounsfield units (HU) of the chondroid matrix as mean, minimum, maximum, and standard deviation (SD) were reviewed on CT scans. Pearson’s correlation analysis was performed to determine the relationship between CT features and SUVmax. Subgroup analysis was also performed between the benign group (enchondroma) and the malignant group (grade 1 and 2 chondrosarcoma) for comparison of HU values and SUVmax. (3) Results: a significant negative correlation between SUVmax and HU measurements, including HUmax, HUmean, and HUSD, was found. The subgroup analysis showed significantly higher SUVmax in the malignant group, with more frequent CT aggressive features, and significantly lower HUSDin the malignant group than in the benign group. (4) Conclusions: it was observed that higher SUVmax and lower HUSDwere associated with a higher probability of having a low-to-intermediate chondrosarcoma with aggressive features and a less calcified tumor matrix.

摘要翻译： 

(1) 背景：软骨性骨肿瘤的准确分级判定具有挑战性。通过骨单光子发射计算机断层扫描（SPECT）/计算机断层扫描（CT）发现，最大标准化摄取值（SUVmax）与软骨性骨肿瘤的不同分级显著相关。本研究重点探讨肿瘤基质对SUVmax的影响。(2) 方法：回顾性纳入2017年至2022年间接受骨SPECT/CT检查的65例中央型软骨性骨肿瘤患者，包括内生软骨瘤及低至中级别软骨肉瘤。记录SUVmax值，并在CT扫描中评估软骨性骨肿瘤的侵袭性CT征象、软骨基质的亨氏单位（HU）值（包括均值、最小值、最大值及标准差）。采用皮尔逊相关性分析CT特征与SUVmax的关系。在良性组（内生软骨瘤）与恶性组（1级和2级软骨肉瘤）之间进行亚组分析，比较HU值和SUVmax的差异。(3) 结果：SUVmax与HU测量值（包括HU最大值、HU均值及HU标准差）呈显著负相关。亚组分析显示，恶性组的SUVmax显著更高，侵袭性CT特征更常见，且恶性组的HU标准差显著低于良性组。(4) 结论：研究发现，较高的SUVmax和较低的HU标准差与低至中级别软骨肉瘤（具有侵袭性特征且钙化程度较低的肿瘤基质）的发生概率较高相关。

原文链接：

Quantitative Bone SPECT/CT of Central Cartilaginous Bone Tumors: Relationship between SUVmax and Radiodensity in Hounsfield Unit