文章：

肺癌中的细胞外囊泡：在诊断中的应用与治疗前景

Extracellular Vesicles in Lung Cancer: Implementation in Diagnosis and Therapeutic Perspectives

原文发布日期：22 May 2024

DOI: 10.3390/cancers16111967

类型: Article

开放获取: 是

英文摘要：

Lung cancer represents the leading cause of cancer-related mortality worldwide, with around 1.8 million deaths in 2020. For this reason, there is an enormous interest in finding early diagnostic tools and novel therapeutic approaches, one of which is extracellular vesicles (EVs). EVs are nanoscale membranous particles that can carry proteins, lipids, and nucleic acids (DNA and RNA), mediating various biological processes, especially in cell–cell communication. As such, they represent an interesting biomarker for diagnostic analysis that can be performed easily by liquid biopsy. Moreover, their growing dataset shows promising results as drug delivery cargo. The aim of our work is to summarize the recent advances in and possible implications of EVs for early diagnosis and innovative therapies for lung cancer.

摘要翻译： 

肺癌是全球癌症相关死亡的主要原因，2020年约导致180万人死亡。因此，寻找早期诊断工具和新型治疗方法备受关注，其中细胞外囊泡（EVs）便是一种重要方向。细胞外囊泡是纳米级的膜性颗粒，能够携带蛋白质、脂质和核酸（DNA与RNA），介导多种生物过程，尤其在细胞间通讯中发挥关键作用。因此，它们可作为极具潜力的生物标志物，通过液体活检便捷地进行诊断分析。此外，日益丰富的研究数据表明，细胞外囊泡作为药物递送载体展现出广阔前景。本文旨在综述细胞外囊泡在肺癌早期诊断与创新治疗领域的最新进展及其潜在应用价值。

原文链接：

Extracellular Vesicles in Lung Cancer: Implementation in Diagnosis and Therapeutic Perspectives