Enhanced screening protocols for cancer detection have increased survival in patients with head and neck cancer (HNC), which highlights the need to address the sequelae of therapy-induced cardiovascular complications. This study was conducted to assess the incidence and risk of acute myocardial infarction (AMI) in patients with HNC who have not undergone radiation or chemotherapy using a comprehensive, population-based cohort dataset. A total of 2976 individuals without cancer and 744 individuals with HNC were matched using the propensity score method. The findings indicated that the occurrence rates of AMI were comparable between the HNC (2.19) and non-cancer groups (2.39). Cox regression analysis did not demonstrate a significant increase in the risk of AMI in patients with HNC (hazard ratio: 0.93, 95% confidence interval: 0.50–1.73). No increased risk of AMI was observed in the HNC group compared to the non-cancer group, regardless of the time since the HNC diagnosis. Subgroup analyses showed no notable differences in the AMI risk between the groups when considering sex, age, comorbidities, and cancer type. This study showed that patients with HNC who have not been treated with radiation or chemotherapy did not exhibit an increased incidence or risk of AMI compared to individuals without cancer.
头颈癌（HNC）患者因癌症检测筛查方案的优化而提高了生存率，这凸显了解决治疗引发心血管并发症后遗症的重要性。本研究旨在利用基于人群的综合队列数据集，评估未接受放疗或化疗的HNC患者急性心肌梗死（AMI）的发生率及风险。通过倾向评分匹配法，共纳入2976名非癌症个体与744名HNC患者。结果显示，HNC组（2.19）与非癌症组（2.39）的AMI发生率相近。Cox回归分析未显示HNC患者的AMI风险显著增加（风险比：0.93，95%置信区间：0.50–1.73）。无论从HNC确诊后多长时间观察，与非癌症组相比，HNC组均未表现出AMI风险升高。亚组分析表明，在考虑性别、年龄、合并症及癌症类型时，两组间的AMI风险无显著差异。本研究表明，与未患癌症的个体相比，未接受放疗或化疗的HNC患者并未表现出AMI发生率或风险的增加。
肿瘤(癌症)患者之家