Compared to adults without cancer, cancer survivors report poorer health-related quality of life (HRQOL), which is associated with negative treatment outcomes and increased healthcare use. Cancer-specialized physical and occupational therapy (PT/OT) could optimize HRQOL; however, the impact among survivors with non-breast malignancies is unknown. This retrospective (2020–2022), observational, study of medical record data of 12 cancer types, examined pre/post-HRQOL among cancer survivors who completed PT/OT. PROMIS®HRQOL measures: Global Health (physical [GPH] and mental [GMH]), Physical Function (PF), and Ability to Participate in Social Roles and Activities (SRA) were evaluated using linear mixed effect models by cancer type, then compared to the minimal important change (MIC, 2 points). Survivors were 65.44 ± 12.84 years old (range: 19–91), male (54%), with a median of 12 visits. Improvements in GPH were significant (p< 0.05) for all cancer types and all achieved MIC. Improvements in GMH were significant for 11/12 cancer types and 8/12 achieved MIC. Improvements in PF were significant for all cancer types and all achieved the MIC. Improvements in SRA were significant for all cancer types and all groups achieved the MIC. We observed statistically and clinically significant improvements in HRQOL domains for each of the 12 cancer types evaluated.
与未患癌症的成年人相比，癌症幸存者报告的健康相关生活质量（HRQOL）较差，这与不良治疗结果和医疗资源使用增加相关。癌症专科物理治疗与作业治疗（PT/OT）可优化HRQOL，但其对非乳腺恶性肿瘤幸存者的影响尚不明确。这项回顾性（2020-2022年）观察性研究通过分析12种癌症类型的医疗记录数据，评估了完成PT/OT治疗的癌症幸存者干预前后的HRQOL变化。采用PROMIS®HRQOL测量工具：通过线性混合效应模型按癌症类型评估总体健康（生理[GPH]与心理[GMH]）、生理功能（PF）及社会角色与活动参与能力（SRA），并与最小重要变化值（MIC，2分）进行比较。幸存者平均年龄65.44±12.84岁（范围：19-91岁），男性占54%，中位治疗次数为12次。所有癌症类型的GPH均呈现显著改善（p<0.05），且均达到MIC标准；11/12癌症类型的GMH改善显著，其中8/12达到MIC；所有癌症类型的PF改善均具有统计学显著性且全部达到MIC；所有癌症类型的SRA改善均显著，且全部达到MIC。研究观察到12种癌症类型在所有HRQOL维度均获得具有统计学意义与临床意义的显著改善。
肿瘤(癌症)患者之家