Cancer cachexia is a multifaceted syndrome that impacts individuals with advanced cancer. It causes numerous pathological changes in cancer patients, such as inflammation and metabolic dysfunction, which further diminish their quality of life. Unfortunately, cancer cachexia also increases the risk of mortality in affected individuals, making it an important area of focus for cancer research and treatment. Several potential nutritional therapies are being tested in preclinical and clinical models for their efficacy in improving muscle metabolism in cancer patients. Despite promising results, no special nutritional therapies have yet been validated in clinical practice. Multiple studies provide evidence of the benefits of increasing muscle protein synthesis through an increased intake of amino acids or protein. There is also increasing evidence that exercise can reduce muscle atrophy by modulating protein synthesis. Therefore, the combination of protein intake and exercise may be more effective in improving cancer cachexia. This review provides an overview of the preclinical and clinical approaches for the use of amino acids with and without exercise therapy to improve muscle metabolism in cachexia.
癌症恶病质是一种影响晚期癌症患者的多层面综合征。它会导致癌症患者出现多种病理变化，如炎症和代谢功能障碍，从而进一步降低其生活质量。不幸的是，癌症恶病质还会增加患者的死亡风险，使其成为癌症研究和治疗的重要关注领域。目前已有多种潜在营养疗法在临床前和临床模型中进行测试，以评估其在改善癌症患者肌肉代谢方面的功效。尽管结果令人鼓舞，但尚未有特殊营养疗法在临床实践中得到验证。多项研究证明，通过增加氨基酸或蛋白质的摄入来提高肌肉蛋白质合成具有益处。越来越多的证据也表明，运动可以通过调节蛋白质合成来减少肌肉萎缩。因此，蛋白质摄入与运动相结合可能更有效地改善癌症恶病质。本综述概述了在恶病质中应用氨基酸（无论是否结合运动疗法）以改善肌肉代谢的临床前和临床研究方法。
Influence of Amino Acids and Exercise on Muscle Protein Turnover, Particularly in Cancer Cachexia
肿瘤(癌症)患者之家