Hyaluronic acid (HA) is a prominent component of the extracellular matrix, and its interactions with HA-interacting molecules (HAIMs) play a critical role in cancer development and disease progression. This review explores the multifaceted role of HAIMs in the context of cancer, focusing on their influence on disease progression by dissecting relevant cellular and molecular mechanisms in tumour cells and the tumour microenvironment. Cancer progression can be profoundly affected by the interactions between HA and HAIMs. They modulate critical processes such as cell adhesion, migration, invasion, and proliferation. The TME serves as a dynamic platform in which HAIMs contribute to the formation of a unique niche. The resulting changes in HA composition profoundly influence the biophysical properties of the TME. These modifications in the TME, in conjunction with HAIMs, impact angiogenesis, immune cell recruitment, and immune evasion. Therefore, understanding the intricate interplay between HAIMs and HA within the cancer context is essential for developing novel therapeutic strategies. Targeting these interactions offers promising avenues for cancer treatment, as they hold the potential to disrupt critical aspects of disease progression and the TME. Further research in this field is imperative for advancing our knowledge and the treatment of cancer.
透明质酸（HA）是细胞外基质的重要组成成分，其与透明质酸相互作用分子（HAIMs）的相互作用在癌症发生发展及疾病进程中起着关键作用。本综述探讨了HAIMs在癌症中的多重作用，重点通过剖析肿瘤细胞及肿瘤微环境中的相关细胞与分子机制，阐明其对疾病进展的影响。HA与HAIMs之间的相互作用可显著影响癌症进展，它们调控细胞黏附、迁移、侵袭和增殖等关键过程。肿瘤微环境作为动态平台，HAIMs参与形成独特的生态位，由此引发的HA组成变化深刻影响着肿瘤微环境的生物物理特性。这些肿瘤微环境的改变与HAIMs共同作用于血管生成、免疫细胞募集及免疫逃逸过程。因此，深入理解癌症背景下HAIMs与HA之间复杂的相互作用机制，对开发新型治疗策略至关重要。针对这些相互作用的靶向治疗为癌症治疗提供了前景广阔的途径，因其具有破坏疾病进展关键环节及肿瘤微环境的潜力。该领域的进一步研究对深化认知和推进癌症治疗具有迫切必要性。
肿瘤(癌症)患者之家