Pulmonary oncological pathologies are an important public health problem and the association with other pulmonary lesions may pose difficulties in diagnosis and staging or require different treatment options. To address this complexity, we conducted a retrospective observational study at the Marius Nasta Institute of Pneumophthisiology, Bucharest, Romania. Our study focused on patients admitted in 2019 with non-small-cell lung carcinoma and associated pulmonary lesions identified through surgical resection specimens. Among the 314 included patients, multiple pulmonary nodules were observed on macroscopic examination, with 12% (N = 37) exhibiting nonmalignant etiologies upon microscopic examination. These findings underscore the challenge of preoperative staging. Patients with coexisting nonmalignant lesions were similar in age, smoking habits, and professional or environmental exposure by comparison with those who presented only malignant lesions. The presentation of coexisting malignant and nonmalignant lesions may pose difficulties in diagnosing and staging pulmonary cancer.
肺肿瘤性病变是重要的公共卫生问题，其与其他肺部病变的关联可能给诊断和分期带来困难，或需要不同的治疗方案。为应对这一复杂性，我们在罗马尼亚布加勒斯特的Marius Nasta肺病研究所开展了一项回顾性观察研究。本研究聚焦于2019年收治的非小细胞肺癌患者，并通过手术切除标本识别出伴随的肺部病变。在纳入的314例患者中，肉眼观察发现多发性肺结节，其中12%（37例）在显微镜检查中显示为非恶性病因。这些发现凸显了术前分期的挑战。与仅存在恶性病变的患者相比，伴有非恶性病变的患者在年龄、吸烟习惯以及职业或环境暴露方面具有相似性。恶性与非恶性病变共存的情况可能给肺癌的诊断和分期带来困难。
Navigating the Maze: Exploring Non-Oncological Complexities in Non-Small-Cell Lung Cancer
肿瘤(癌症)患者之家