文章：

抗癌药物研发的历史沿革与当代趋势

Historical Perspective and Current Trends in Anticancer Drug Development

原文发布日期：15 May 2024

DOI: 10.3390/cancers16101878

类型: Article

开放获取: 是

英文摘要：

Cancer is considered one of the leading causes of death in the 21st century. The intensive search for new anticancer drugs has been actively pursued by chemists and pharmacologists for decades, focusing either on the isolation of compounds with cytotoxic properties from plants or on screening thousands of synthetic molecules. Compounds that could potentially become candidates for new anticancer drugs must have the ability to inhibit proliferation and/or induce apoptosis in cancer cells without causing too much damage to normal cells. Some anticancer compounds were discovered by accident, others as a result of long-term research. In this review, we have presented a brief history of the development of the most important groups of anticancer drugs, pointing to the fact that they all have many side effects.

摘要翻译： 

癌症被视为21世纪的主要死因之一。数十年来，化学家和药理学家一直积极致力于新型抗癌药物的探索，其研究重点主要集中在从植物中分离具有细胞毒性的化合物，或对数千种合成分子进行筛选。可能成为新型抗癌药物候选的化合物必须具备抑制癌细胞增殖和/或诱导癌细胞凋亡的能力，同时不对正常细胞造成过度损伤。部分抗癌化合物的发现源于偶然，另一些则是长期系统研究的成果。本综述简要回顾了最重要几类抗癌药物的发展历程，并指出这些药物均存在诸多副作用。

原文链接：

Historical Perspective and Current Trends in Anticancer Drug Development