Purpose: Pancreatic cancer (PC) is a fatal malignancy with an aggressive course derived from the cells of pancreatic tissue. Gestational diabetes mellitus (GDM) is a state of spontaneous hyperglycemia occurring during gestation and has been suggested as a risk factor PC. Women with a history of GDM revealed a risk rate of 7.1% for the development of PC. The current systematic review aims to investigate the correlation between GDM and the degree to the prevalence of PC. Methodology: For this systematic review, the PICO model was prepared to construct and outline the exact questions of the study, a PRISMA flow diagram was prepared and quality assessment was conducted using the Newcastle Ottawa Scale (NOS) for Cohort Studies, the NIH Quality Assessment Tool-Criteria for Case Reports and the Cochrane quality assessment tool for Systematic Reviews and Meta-analysis studies. Result: A total of eight articles were retrieved from the main databases, and a table was created to summarize the information found. Even though the data found were limited, the quality assessment performed revealed that the articles were of high validity. Conclusions: It can be concluded that GDM has an association with the development of PC and can be considered as a risk factor.
目的：胰腺癌（PC）是一种源于胰腺组织细胞的致命性恶性肿瘤，病程进展迅速。妊娠期糖尿病（GDM）是妊娠期间发生的自发性高血糖状态，已被认为是胰腺癌的潜在风险因素。有GDM病史的女性罹患胰腺癌的风险率为7.1%。本系统性综述旨在探究GDM与胰腺癌患病率之间的关联程度。方法：本研究采用PICO模型构建并明确研究问题，绘制PRISMA流程图，并运用纽卡斯尔-渥太华量表（NOS）评估队列研究质量，采用美国国立卫生研究院病例报告质量评估工具及Cochrane系统综述与荟萃分析研究质量评估工具进行质量评价。结果：从主要数据库共检索到八篇文献，通过表格形式对研究信息进行汇总。尽管现有数据有限，但质量评估显示这些文献具有较高的有效性。结论：可以认为GDM与胰腺癌的发生存在关联，可被视为风险因素之一。
肿瘤(癌症)患者之家