Angiosarcoma is a rare aggressive and understudied soft tissue sarcoma with pending evidence-based treatment guidelines due to varying study cohorts and inconsistent outcome measures. Surgery with wide resection is currently considered to be the cornerstone in management. In a population-based cohort identified from Danish National Health Registers between 2000 and 2017, this study aimed to define prognostic factors in patients with newly diagnosed soft tissue angiosarcoma. Kaplan–Meier survival analysis demonstrated 5-year overall survival of 28%. Competing risk analysis demonstrated cumulative incidence of local recurrence of 30% and metastasis of 43%. Multivariable Cox models among 154 included patients demonstrated age above 60 years and metastasis to be independently associated with worse overall survival. Cutaneous tumors, surgery, and negative resection margin were independently associated with improved overall survival. Adjuvant oncological treatment did not improve overall survival, risk of metastasis, or recurrence. Negative margin was not associated with lower risk of recurrence and metastasis. We conclude that, despite demonstrated improved survival after surgery with wide resection, overall survival remains poor.
血管肉瘤是一种罕见且具有侵袭性的软组织肉瘤，目前研究尚不充分。由于研究队列差异及结局指标不一致，其循证治疗指南尚未确立。目前广泛切除手术被认为是治疗的基石。本研究基于2000年至2017年丹麦国家健康登记系统的人群队列，旨在明确新诊断软组织血管肉瘤患者的预后因素。Kaplan-Meier生存分析显示5年总生存率为28%。竞争风险分析显示局部复发累积发生率为30%，远处转移为43%。对154例患者的多元Cox模型分析表明，年龄超过60岁及存在转移是总生存率降低的独立相关因素。而皮肤来源肿瘤、接受手术治疗以及切缘阴性则与总生存率改善独立相关。辅助肿瘤治疗未能改善总生存率、转移风险或复发风险。阴性切缘与降低复发和转移风险无显著关联。我们的结论是：尽管广泛切除手术被证实可改善生存，但血管肉瘤患者的总体生存状况仍然较差。
肿瘤(癌症)患者之家