This study aims to evaluate several defined specimen parameters that would allow to determine the surgical accuracy of breast-conserving surgeries (BCS) in a representative population of patients. These specimen parameters could be used to compare surgical accuracy when using novel technologies for intra-operative BCS guidance in the future. Different specimen parameters were determined among 100 BCS patients, including the ratio of specimen volume to tumor volume (resection ratio) with different optimal margin widths (0 mm, 1 mm, 2 mm, and 10 mm). Furthermore, the tumor eccentricity [maximum tumor-margin distance − minimum tumor-margin distance] and the relative tumor eccentricity [tumor eccentricity ÷ pathological tumor diameter] were determined. Different patient subgroups were compared using Wilcoxon rank sum tests. When using a surgical margin width of 0 mm, 1 mm, 2 mm, and 10 mm, on average, 19.16 (IQR 44.36), 9.94 (IQR 18.09), 6.06 (IQR 9.69) and 1.35 (IQR 1.78) times the ideal resection volume was excised, respectively. The median tumor eccentricity among the entire patient population was 11.29 mm (SD = 3.99) and the median relative tumor eccentricity was 0.66 (SD = 2.22). Resection ratios based on different optimal margin widths (0 mm, 1 mm, 2 mm, and 10 mm) and the (relative) tumor eccentricity could be valuable outcome measures to evaluate the surgical accuracy of novel technologies for intra-operative BCS guidance.
本研究旨在评估若干明确的标本参数，以确定代表性患者群体中保乳手术（BCS）的手术精确度。这些标本参数可用于未来比较采用新型术中BCS引导技术时的手术准确性。研究对100例BCS患者测定了不同标本参数，包括采用不同最佳切缘宽度（0毫米、1毫米、2毫米和10毫米）时标本体积与肿瘤体积的比值（切除比）。此外，还测定了肿瘤偏心率[最大肿瘤-切缘距离−最小肿瘤-切缘距离]和相对肿瘤偏心率[肿瘤偏心率÷病理肿瘤直径]。采用Wilcoxon秩和检验对不同患者亚组进行比较。当采用0毫米、1毫米、2毫米和10毫米手术切缘宽度时，切除的组织体积平均分别为理想切除体积的19.16倍（四分位距44.36）、9.94倍（四分位距18.09）、6.06倍（四分位距9.69）和1.35倍（四分位距1.78）。全体患者的中位肿瘤偏心率为11.29毫米（标准差=3.99），中位相对肿瘤偏心率为0.66（标准差=2.22）。基于不同最佳切缘宽度（0毫米、1毫米、2毫米和10毫米）的切除比及（相对）肿瘤偏心率，可作为评估新型术中BCS引导技术手术精确度的有效结局指标。
肿瘤(癌症)患者之家