Representing the second most common skin cancer, the incidence and disease burden of cutaneous squamous cell carcinoma (cSCC) continues to increase. Surgical excision of the primary site effectively cures the majority of cSCC cases. However, an aggressive subset of cSCC persists with clinicopathological features that are indicative of higher recurrence, metastasis, and mortality risks. Acceleration of these features is driven by a combination of genetic and environmental factors. The past several years have seen remarkable progress in shaping the treatment landscape for advanced cSCC. Risk stratification and clinical management is a top priority. This review provides an overview of the current perspectives on cSCC with a focus on staging, treatment, and maintenance strategies, along with future research directions.
作为第二常见的皮肤癌，皮肤鳞状细胞癌（cSCC）的发病率与疾病负担持续上升。手术切除原发灶可有效治愈大多数cSCC病例。然而，部分侵袭性cSCC具有提示更高复发、转移及死亡风险的临床病理特征。这些特征的加速发展由遗传与环境因素共同驱动。近年来，晚期cSCC的治疗格局取得了显著进展，风险分层与临床管理已成为首要任务。本综述概述当前对cSCC的认知进展，重点聚焦分期、治疗与维持策略，并展望未来研究方向。
肿瘤(癌症)患者之家