This study uses Monte Carlo simulation and experimental measurements to develop a predictive model for estimating the external dose rate associated with permanent radioactive source implantation in prostate cancer patients. The objective is to estimate the accuracy of the patient’s external dose rate measurement. First, I-125 radioactive sources were implanted into Mylar window water phantoms to simulate the permanent implantation of these sources in patients. Water phantom experimental measurement was combined with Monte Carlo simulation to develop predictive equations, whose performance was verified against external clinical data. The model’s accuracy in predicting the external dose rate in patients with permanently implanted I-125 radioactive sources was high (R2= 0.999). A comparative analysis of the experimental measurements and the Monte Carlo simulations revealed that the maximum discrepancy between the measured and calculated values for the water phantom was less than 5.00%. The model is practical for radiation safety assessments, enabling the evaluation of radiation exposure risks to individuals around patients with permanently implanted I-125 radioactive sources.
本研究采用蒙特卡洛模拟与实验测量相结合的方法，构建了用于评估前列腺癌患者永久性放射性粒子植入后外照射剂量率的预测模型，旨在验证患者外照射剂量率测量的准确性。首先，将碘-125放射性粒子植入聚酯薄膜水模体，模拟粒子在患者体内的永久性植入状态。通过水模体实验测量与蒙特卡洛模拟的协同分析，建立了预测方程，并利用外部临床数据验证了其性能。该模型对永久性植入碘-125放射性粒子患者外照射剂量率的预测精度较高（R²=0.999）。实验测量与蒙特卡洛模拟的对比分析表明，水模体测量值与计算值的最大偏差小于5.00%。该模型适用于辐射安全评估，能够有效评估永久性植入碘-125放射性粒子患者周围人群的辐射暴露风险。
肿瘤(癌症)患者之家