Modern chemotherapies offer a broad approach to cancer treatment but eliminate both cancer and non-cancer cells indiscriminately and, thus, are associated with a host of side effects. Advances in precision oncology have brought about new targeted therapeutics, albeit mostly limited to a subset of patients with an actionable mutation. They too come with side effects and, ultimately, ‘self-resistance’ to the treatment. There is recent interest in the modulation of ion channels, transmembrane proteins that regulate the flow of electrically charged molecules in and out of cells, as an approach to aid treatment of cancer. Phytochemicals have been shown to act on ion channels with high specificity regardless of the tumor’s genetic profile. This paper explores the use of phytochemicals in cancer symptom management and treatment.
现代化疗为癌症治疗提供了广泛手段，但其在杀灭癌细胞的同时会无差别清除非癌细胞，因而伴随一系列副作用。精准肿瘤学的进展催生了新型靶向疗法，然而这些疗法大多仅适用于携带特定可操作基因突变的患者群体，同样存在副作用，并最终可能引发治疗性"自我抵抗"。近期研究关注离子通道调控——这类跨膜蛋白可调节带电分子在细胞内外流动——将其作为辅助癌症治疗的潜在途径。植物化学物质已被证实能高特异性作用于离子通道，且不受肿瘤基因谱影响。本文系统探讨植物化学物质在癌症症状管理与治疗中的应用前景。
Phytochemical Modulation of Ion Channels in Oncologic Symptomatology and Treatment
肿瘤(癌症)患者之家