There is limited information on whether the COVID-19 pandemic was associated with decreased breast cancer screening uptake and if COVID-19 vaccination was associated with an increase in screening uptake. Our study explored the uptake of breast cancer screening in Japan after the COVID-19 pandemic and assessed its association with the COVID-19 vaccination. We analyzed data from the Japan COVID-19 and Society Internet Survey (JACSIS), a web-based prospective cohort survey, and we included 6110 women without cancer history who were aged 40 to 74 years that participated in the 2012 and 2022 surveys. We examined the regular breast cancer screening uptake before and after the pandemic and employed a multivariable Poisson regression model to seek any association between COVID-19 vaccination and screening uptake. Of 6110, 38.2% regularly participated in screening before the pandemic and 46.9% did so after the pandemic. Individuals unvaccinated due to health reasons (incidence rate ratio (IRR) = 0.47, 95% CI: 0.29–0.77,p= 0.003) and for other reasons (IRR = 0.73, 95% CI: 0.62–0.86,p< 0.001) were less likely to undergo screening compared to fully vaccinated individuals. There was no long-term decrease in breast cancer screening uptake after the pandemic in Japan. Vaccination was linked to increased uptake, but there was no dose relationship.
关于COVID-19大流行是否与乳腺癌筛查参与率下降相关，以及COVID-19疫苗接种是否与筛查参与率提升存在关联，目前相关信息有限。本研究探讨了日本在COVID-19大流行后乳腺癌筛查的参与情况，并评估其与COVID-19疫苗接种的关联性。我们分析了基于网络的前瞻性队列调查"日本COVID-19与社会网络调查"（JACSIS）的数据，纳入了参与2012年和2022年调查的6110名40至74岁无癌症病史的女性。我们考察了大流行前后定期乳腺癌筛查的参与情况，并采用多变量泊松回归模型探究COVID-19疫苗接种与筛查参与之间的关联。在6110名受访者中，大流行前定期参与筛查的比例为38.2%，大流行后这一比例升至46.9%。与完成全程疫苗接种者相比，因健康原因未接种者（发病率比[IRR]=0.47，95% CI：0.29-0.77，p=0.003）及其他原因未接种者（IRR=0.73，95% CI：0.62-0.86，p<0.001）参与筛查的可能性显著降低。日本在疫情后未出现乳腺癌筛查参与率的长期下降趋势。疫苗接种与筛查参与率提升相关，但未发现剂量依赖关系。
肿瘤(癌症)患者之家