Because of the high prevalence of bone destruction in patients with multiple myeloma (MM), physical exercise is oftentimes discouraged by healthcare providers. The goal of this prospective trial was to investigate the feasibility of two six-month exercise interventions in patients with MM (N= 42): a remotely prompted home-based walking intervention or a supervised strength training intervention. Physical function and pain were assessed with the Activity Measure for Post-Acute Care (AM-PAC) Basic Mobility Short Form raw score, a six-minute walk test (6 MWT), a 30-second sit-to-stand test (30 SST), a timed up-and-go (TUG) test, a visual analog scale (VAS) for pain, handheld dynamometer tests, heart rate at rest, blood oxygen saturation at rest, and body mass index. No intervention-related serious adverse events were observed. Adverse events mostly affected the musculoskeletal system. In the resistance training group (n= 24), patients showed significant improvements in AM-PAC, TUG, 6 MWT, and 30 SST, with all effects but the 6 MWT sustained six months after the intervention. The walking group (n= 18) saw improvements in the AM-PAC, TUG, 6 MWT, and 30 SST, with a sustained change in the AM-PAC and TUG. This trial shows the feasibility of both exercise interventions with a sustained beneficial effect on the physical functioning of a six-month strength training intervention and, to a lesser extent, a six-month unsupervised walking intervention. A larger study building on these findings is currently underway.
由于多发性骨髓瘤（MM）患者骨质破坏发生率较高，医护人员通常不建议其进行体育锻炼。本前瞻性试验旨在探讨两种为期六个月的锻炼干预方案在MM患者（N=42）中的可行性：远程提示的家庭步行干预或监督下的力量训练干预。通过急性后期照护活动测量基本移动能力简表原始评分、六分钟步行试验、30秒坐立试验、计时起立行走测试、疼痛视觉模拟评分、手持式测力计测试、静息心率、静息血氧饱和度及身体质量指数，对患者身体功能与疼痛状况进行评估。试验期间未观察到与干预相关的严重不良事件，不良事件主要影响肌肉骨骼系统。在抗阻训练组（n=24）中，患者在急性后期照护活动测量、计时起立行走、六分钟步行及30秒坐立测试方面均呈现显著改善，除六分钟步行外所有改善效果在干预结束后六个月仍得以保持。步行组（n=18）在急性后期照护活动测量、计时起立行走、六分钟步行及30秒坐立测试方面均有改善，其中急性后期照护活动测量与计时起立行走的改善效果具有持续性。本试验证明两种锻炼干预方案均具可行性，其中为期六个月的力量训练干预对患者身体功能具有持续改善作用，而六个月无监督步行干预的改善效果相对有限。基于这些发现开展的更大规模研究目前正在进行中。
肿瘤(癌症)患者之家