Preserving maximum lung function is a fundamental goal of parenchymal-sparing pulmonary laser surgery. Long-term studies for follow-up of lung function after pulmonary laser metastasectomy are lacking. However, a sufficient postoperative lung function is essential for quality of life and reduces potential postoperative complications. In this study, we investigate the extent of loss in lung function following pulmonary laser resection after three, six, and twelve months. We conducted a retrospective analysis using a prospective database of 4595 patients, focusing on 126 patients who underwent unilateral pulmonary laser resection for lung metastases from 1996 to 2022 using a 1318 nm Nd:YAG laser or a high-power pure diode laser. Results show that from these patients, a median of three pulmonary nodules were removed, with 75% presenting central lung lesions and 25% peripheral lesions. The median preoperative FEV1was 98% of the predicted value, decreasing to 71% postoperatively but improving to 90% after three months, 93% after six months, and 96% after twelve months. Statistical analysis using the Friedman test indicated no significant difference in FEV1between preoperative levels and those at six and twelve months post-surgery. The findings confirm that pulmonary laser surgery effectively preserves lung function over time, with patients generally regaining their preoperative lung function within a year, regardless of the metastases’ location.
保留最大肺功能是肺实质保留性激光手术的基本目标。目前尚缺乏关于肺激光转移瘤切除术后肺功能长期随访的研究。然而，足够的术后肺功能对生活质量至关重要，并能减少潜在的术后并发症。本研究旨在探讨肺激光切除术后三个月、六个月及十二个月肺功能损失的程度。我们利用前瞻性数据库对4595例患者进行回顾性分析，重点关注1996年至2022年间接受单侧肺激光切除术治疗肺转移瘤的126例患者，手术采用1318 nm Nd:YAG激光或高功率纯二极管激光。结果显示，这些患者中位切除肺结节数为3个，其中75%为中央型肺病变，25%为周围型病变。术前第一秒用力呼气容积中位数为预测值的98%，术后降至71%，但三个月后恢复至90%，六个月后达93%，十二个月后达到96%。弗里德曼检验统计分析表明，术前与术后六个月、十二个月的第一秒用力呼气容积无显著差异。研究结果证实，肺激光手术能随时间推移有效保留肺功能，无论转移瘤位置如何，患者通常在一年内基本恢复术前肺功能水平。
肿瘤(癌症)患者之家