文章：

搭建社区桥梁：一项针对头颈癌患者结合物理治疗与抗阻锻炼干预的实用随机对照试验

Building a Bridge to Community: A Pragmatic Randomized Trial Examining a Combined Physical Therapy and Resistance Exercise Intervention for People after Head and Neck Cancer

原文发布日期：1 May 2024

DOI: 10.3390/cancers16091758

类型: Article

开放获取: 是

英文摘要：

Background: Established barriers to general exercise and physical activity among individuals with head and neck cancer include dry mouth, difficulty eating, weight loss, fear of injury, comorbidities, and treatment-related symptoms of pain and fatigue. Methods/Design: A 12-week pragmatic randomized controlled trial was conducted followed by an optional supported exercise transition phase. Eligible participants were individuals with head and neck cancers who had undergone surgery and/or radiation therapy to lymph node regions in the neck. Participants were randomized to a comparison group involving a shoulder and neck physiotherapeutic exercise protocol, or to a combined experimental group comprising the shoulder and neck physiotherapeutic exercise protocol and lower-body resistance exercise training. The primary outcome of this study was fatigue-related quality of life. Results: Sixty-one participants enrolled, 59 (97%) completed the randomized trial phase, 55 (90%) completed the 24-week follow-up, and 52 (85%) completed the one-year follow-up. Statistically significant between-group differences were found in favor of the combined experimental group for the fatigue-related quality of life, fitness outcomes, and overall physical activity. Paired comparisons confirmed significant within-group improvements for both groups from baseline to one-year follow-up across most outcomes. Discussion: A group-based combined physiotherapeutic and lower-body resistance exercise program was feasible and effective. Findings are limited to individuals who had undergone a surgical neck dissection procedure. Given the complexity of head and neck cancer, further pragmatic interdisciplinary research is warranted.

摘要翻译： 

背景：头颈癌患者进行常规锻炼和身体活动的主要障碍包括口干、进食困难、体重减轻、对受伤的恐惧、合并症以及治疗相关的疼痛和疲劳症状。方法/设计：本研究进行了一项为期12周的实用性随机对照试验，随后为可选的支持性运动过渡阶段。符合条件的参与者为接受过颈部淋巴结区域手术和/或放射治疗的头颈癌患者。参与者被随机分配到对照组（接受肩颈部物理治疗锻炼方案）或联合实验组（接受肩颈部物理治疗锻炼方案结合下肢抗阻训练）。本研究的主要结果是疲劳相关生活质量。结果：共61名参与者入组，其中59人（97%）完成随机试验阶段，55人（90%）完成24周随访，52人（85%）完成一年随访。在疲劳相关生活质量、体能结果和总体身体活动方面，联合实验组显示出具有统计学意义的组间优势。配对比较证实，从基线到一年随访，两组在大多数结果指标上均出现显著的组内改善。讨论：基于群体的物理治疗结合下肢抗阻训练方案具有可行性和有效性。研究结果仅限于接受过颈部淋巴结清扫手术的患者。鉴于头颈癌的复杂性，有必要开展进一步的实用性跨学科研究。

原文链接：

Building a Bridge to Community: A Pragmatic Randomized Trial Examining a Combined Physical Therapy and Resistance Exercise Intervention for People after Head and Neck Cancer