文章：

重新评估声波刺猬信号通路在肝细胞癌中的作用

Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma

原文发布日期：29 April 2024

DOI: 10.3390/cancers16091739

类型: Article

开放获取: 是

英文摘要：

HCC remains one of the leading causes of cancer-related death globally. The main challenges in treatments of hepatocellular carcinoma (HCC) primarily arise from high rates of postoperative recurrence and the limited efficacy in treating advanced-stage patients. Various signaling pathways involved in HCC have been reported. Among them, the Sonic hedgehog (SHH) signaling pathway is crucial. The presence of SHH ligands is identified in approximately 60% of HCC tumor tissues, including tumor nests. PTCH-1 and GLI-1 are detected in more than half of HCC tissues, while GLI-2 is found in over 84% of HCC tissues. The SHH signaling pathway (including canonical and non-canonical) is involved in different aspects of HCC, including hepatocarcinogenesis, tumor growth, tumor invasiveness, progression, and migration. The SHH signaling pathway also contributes to recurrence, metastasis, modulation of the cancer microenvironment, and sustaining cancer stem cells. It also affects the resistance of HCC cells to chemotherapy, target therapy, and radiotherapy. Reappraisal of the roles of the SHH signaling pathway in HCC may trigger some novel therapies for HCC.

摘要翻译： 

肝细胞癌（HCC）仍是全球癌症相关死亡的主要原因之一。肝细胞癌治疗面临的主要挑战，源于术后高复发率以及对晚期患者治疗效果有限。已有研究报道了多种参与HCC发生的信号通路，其中声波刺猬（SHH）信号通路至关重要。约60%的HCC肿瘤组织（包括癌巢）中可检测到SHH配体存在。超过半数的HCC组织中可检测到PTCH-1和GLI-1，而GLI-2在超过84%的HCC组织中被发现。SHH信号通路（包括经典与非经典途径）参与HCC发生的多个方面，包括肝癌发生、肿瘤生长、侵袭性、进展和迁移。该通路还促进肿瘤复发与转移，调节肿瘤微环境，维持癌症干细胞特性，并影响HCC细胞对化疗、靶向治疗及放疗的耐药性。重新评估SHH信号通路在HCC中的作用，可能为肝癌治疗带来新的治疗策略。

原文链接：

Reappraisal of the Roles of the Sonic Hedgehog Signaling Pathway in Hepatocellular Carcinoma