文章：

垂体神经内分泌肿瘤表型转化

Phenotype Transformation of PitNETs

原文发布日期：29 April 2024

DOI: 10.3390/cancers16091731

类型: Article

开放获取: 是

英文摘要：

Phenotype transformation in pituitary neuroendocrine tumors is a little-known and unpredictable clinical phenomenon. Previous studies have not clearly defined and systematically concluded on the causes of this rare phenomenon. Additionally, the mechanisms of phenotype transformation are not well known. We reviewed cases reported in the literature with the aim of defining phenotype transformation in pituitary neuroendocrine tumors. We present an overview of the wide spectrum of phenotype transformation and its clinical features. We also discuss findings on the potential mechanism of this rare transformation, which may be related to PC1/3, the bioactivity of secretory hormones, gene mutations and the plasticity of pituitary neuroendocrine tumors. Clinicians should be aware of this rare phenomenon and more studies on the underlying mechanisms are required.

摘要翻译： 

垂体神经内分泌肿瘤的表型转化是一种鲜为人知且难以预测的临床现象。既往研究尚未对这一罕见现象的成因进行明确定义和系统总结，其转化机制亦不明确。本文通过综述文献报道的病例，旨在明确垂体神经内分泌肿瘤表型转化的定义，系统阐述其多样化的表型转化谱系及临床特征，并探讨该罕见转化现象的潜在机制——可能与PC1/3蛋白、分泌激素的生物活性、基因突变及垂体神经内分泌肿瘤的可塑性相关。临床医师需关注这一罕见现象，未来需开展更多针对其潜在机制的研究。

原文链接：

Phenotype Transformation of PitNETs