Surgery plays a central role in the diagnosis, staging, and management of pleural mesothelioma. Achieving an accurate diagnosis through surgical intervention and identifying the specific histologic subtype is crucial for determining the appropriate course of treatment. The histologic subtype guides decisions regarding the use of chemotherapy, immunotherapy, or multimodality treatment. The goal of surgery as part of multimodality treatment is to accomplish macroscopic complete resection with the eradication of grossly visible and palpable disease. Over the past two decades, many medical centers worldwide have shifted from performing extra-pleural pneumonectomy (EPP) to pleurectomy decortication (PD). This transition is motivated by the lower rates of short-term mortality and morbidity associated with PD and similar or even better long-term survival outcomes, compared to EPP. This review aims to outline the role of surgery in diagnosing, staging, and treating patients with pleural mesothelioma.
手术在胸膜间皮瘤的诊断、分期和治疗中扮演着核心角色。通过手术干预获得准确诊断并明确具体组织学亚型，对于确定合适的治疗方案至关重要。组织学亚型将指导化疗、免疫治疗或多模式治疗的选择。作为多模式治疗的一部分，手术的目标是实现肉眼完全切除，清除所有可见及可触及的病灶。过去二十年间，全球许多医疗中心已从开展胸膜外全肺切除术转向胸膜切除/剥脱术。这一转变源于胸膜切除/剥脱术相较于胸膜外全肺切除术具有更低的短期死亡率和并发症发生率，且能获得相似甚至更优的长期生存结果。本文旨在概述手术在胸膜间皮瘤患者诊断、分期和治疗中的作用。
肿瘤(癌症)患者之家