(1) Background: Renal-cell carcinoma (RCC) incidence has been steadily rising, with obesity identified as a potential risk factor. However, the relationship between obesity and RCC prognosis remains unclear. This systematic review aims to investigate the impact of different adipose tissue measurements on RCC behavior and prognosis. (2) Methods: A search of MEDLINE databases identified 20 eligible studies focusing on various fat measurements, including visceral adipose tissue (VAT), subcutaneous adipose tissue (SAT), perirenal adipose tissue (PRAT), and the Mayo adhesive probability (MAP) score. (3) Results: The review revealed conflicting findings regarding the association between adipose tissue measurements and RCC outcomes. While some studies suggested a protective role of certain fat deposits, particularly VAT, against disease progression and mortality, others reported contradictory results across different adipose metrics and RCC subtypes. (4) Conclusions: Methodological variations and limitations, such as retrospective designs and sample size constraints, pose challenges to standardization and generalizability. Further research is needed to understand these associations better and establish standardized approaches for adiposity assessment in RCC patients, which could inform clinical practice and therapeutic decision-making.
（1）背景：肾细胞癌（RCC）发病率持续上升，肥胖已被确认为潜在风险因素。然而，肥胖与RCC预后的关系尚不明确。本系统综述旨在探讨不同脂肪组织测量指标对RCC生物学行为及预后的影响。（2）方法：通过检索MEDLINE数据库，共纳入20项符合条件的研究，重点关注内脏脂肪组织（VAT）、皮下脂肪组织（SAT）、肾周脂肪组织（PRAT）及梅奥粘连概率（MAP）评分等多种脂肪测量指标。（3）结果：综述显示脂肪组织测量指标与RCC预后之间的关联存在矛盾结论。部分研究表明特定脂肪沉积（尤其是VAT）对疾病进展和死亡率具有保护作用，而其他研究在不同脂肪指标与RCC亚型中报告了相反结果。（4）结论：回顾性研究设计和样本量限制等方法学差异与局限性，对研究标准化和结果普适性构成挑战。未来需进一步深入研究这些关联，并建立RCC患者肥胖评估的标准化方法，以期为临床实践和治疗决策提供依据。
肿瘤(癌症)患者之家