Metastases are the most frequent intracranial malignant tumors in adults. While Karnofsky Performance Status (KPS) and Clinical Frailty Scale (CFS) are known to have significant impact on overall survival (OS), temporal muscle thickness (TMT) has been postulated to be a promising new parameter to estimate prognosis. Patients who received a resection of one to three brain metastases in our institution were included. Temporal muscle thickness was measured in preoperative MRI scans according to a standardized protocol. In 199 patients, the mean TMT was 7.5 mm (95CI 7.3–7.7) and the mean OS during follow-up was 31.3 months (95CI 24.2–38.3). There was no significant correlation of TMT and preoperative or follow-up CFS and KPS. While CFS and KPS did significantly correlate with OS (p< 0.001 for each), no correlation was demonstrated for TMT. CFS showed a superior prognostic value compared to KPS. TMT failed to show a significant impact on OS or patient performance, whereas the clinical scales (KPS and CFS) demonstrate a good correlation with OS. Due to its superiority over KPS, we strongly recommend the use of CFS to estimate OS in patients with brain metastases.
转移瘤是成人最常见的颅内恶性肿瘤。尽管已知卡氏功能状态评分（KPS）和临床衰弱量表（CFS）对总生存期（OS）具有显著影响，但颞肌厚度（TMT）被认为是一种评估预后的有前景的新参数。本研究纳入了在本机构接受一至三处脑转移瘤切除术的患者。根据标准化方案在术前MRI扫描中测量颞肌厚度。在199例患者中，平均TMT为7.5毫米（95%CI 7.3-7.7），随访期间平均OS为31.3个月（95%CI 24.2-38.3）。TMT与术前或随访时的CFS和KPS无显著相关性。虽然CFS和KPS与OS显著相关（p<0.001），但TMT未显示相关性。与KPS相比，CFS显示出更优的预后价值。TMT未能显示对OS或患者功能状态的显著影响，而临床量表（KPS和CFS）则与OS呈现良好相关性。鉴于CFS优于KPS，我们强烈推荐使用CFS评估脑转移瘤患者的总生存期。
肿瘤(癌症)患者之家