Melatonin, primarily synthesized in the pineal gland, plays a crucial role in regulating circadian rhythms and possesses significant antioxidative properties. By neutralizing free radicals and reducing oxidative stress, melatonin emerges as a promising agent for the prevention and therapy of many different disorders, including cancer. This paper reviews the relationship between the thyroid gland and melatonin, presenting experimental evidence on the protective effects of this indoleamine against oxidative damage to macromolecules in thyroid tissue caused by documented carcinogens (as classified by the International Agency for Research on Cancer, IARC) or caused by potential carcinogens. Furthermore, the possible influence on cancer therapy in humans and the overall well-being of cancer patients are discussed. The article highlights melatonin’s essential role in maintaining thyroid health and its contribution to management strategies in patients with thyroid cancer and other thyroid diseases.
褪黑素主要由松果体合成，在调节昼夜节律方面发挥关键作用，并具有显著的抗氧化特性。通过中和自由基和减轻氧化应激，褪黑素成为预防和治疗多种疾病（包括癌症）的潜在有效物质。本文综述了甲状腺与褪黑素之间的关系，通过实验证据展示了这种吲哚胺对国际癌症研究机构（IARC）确认的致癌物或潜在致癌物引起的甲状腺组织大分子氧化损伤的保护作用。此外，文章还探讨了褪黑素对人类癌症治疗及癌症患者整体健康状况可能产生的影响。本文重点阐述了褪黑素在维持甲状腺健康中的重要作用，及其对甲状腺癌和其他甲状腺疾病患者管理策略的贡献。
Protective Effects of Melatonin against Carcinogen-Induced Oxidative Damage in the Thyroid
肿瘤(癌症)患者之家