Invasive lobular carcinoma of the breast has different mammographic appearances, including spiculated or lobulated masses, architectural distortion, increased breast density, and the possibility of also being occult. Histologically, the morphology is also variable, as several patterns have been described beside the classical one, including the solid, the alveolar, the trabecular, the one with tubular elements, and others. Of 146 ILC cases, 141 were reviewed for mammographic appearance and 136 for histological patterns by two radiologist and two pathologists, respectively; 132 common cases were analyzed for possible associations between mammographic presentation and the histological patterns. Interobserver agreement on the presence or absence of a given mammographic morphology ranged from 45% (increased density) to 95% (occult lesion); the most common radiomorphology was that of a spiculated mass. Interobserver agreement on the presence or absence of a given histological pattern ranged between 79% (solid) and 99% (classical) but was worse when semi-quantification was also included. The mammography–pathology correlation was less than optimal. Multifocality was more commonly detected by histology. The identification of a mammographic mass lesion often coincided with a mass-like lesion on the histological slides and vice versa, but nearly half of the mammographically occult lesions were felt to have masses on histological slides assessed grossly. Histological patterns showed no obvious associations with one or the other mammographic appearance.
乳腺浸润性小叶癌在乳腺X线摄影中呈现不同的影像学表现，包括毛刺状或分叶状肿块、结构扭曲、乳腺密度增高，亦可能呈隐匿性表现。组织学上其形态学表现同样具有多样性，除经典型外已描述多种亚型，包括实性型、腺泡型、小梁型、伴管状结构型及其他类型。本研究由两名放射科医师与两名病理科医师分别对146例浸润性小叶癌病例进行回顾分析，其中141例评估影像学表现，136例评估组织学模式；最终对132例共同病例进行影像学表现与组织学模式关联性分析。观察者间对特定乳腺X线形态存在与否的判断一致性从45%（密度增高）到95%（隐匿性病灶）不等，其中最常见的影像形态为毛刺状肿块。观察者间对特定组织学模式存在与否的判断一致性介于79%（实性型）至99%（经典型）之间，但加入半定量评估后一致性降低。影像学与病理学相关性未达理想状态。组织学检测多灶性病变更为常见。影像学发现的肿块性病变常与组织切片中的肿块样病变相对应，反之亦然，但近半数影像学隐匿性病变在组织学大体评估中被认为存在肿块。组织学模式与特定影像学表现未呈现明显关联。
肿瘤(癌症)患者之家