The standard procedure for diagnosis and treatment of bladder tumours, transurethral resection of bladder tumour (TURBT), is associated with a complication rate of up to 26% and potentially has severe influence on patient-reported outcomes (PRO). Outpatient transurethral laser ablation (TULA) is an emerging new modality that is less invasive with a lower risk of complications and, thereby, possibly enhanced PRO. We collected PRO following transurethral procedures in treatment of bladder tumours to evaluate any clinically relevant differences in symptoms and side effects. This prospective observational study recruited consecutive patients undergoing different bladder tumour-related transurethral procedures. Patients filled out questionnaires regarding urinary symptoms (ICIQ-LUTS), postoperative side effects, and quality of life (EQ-5D-3L) at days 1 and 14 postoperatively. In total, 108 patients participated. The most frequently reported outcomes were postoperative haematuria and pain. Patients undergoing TURBT reported longer lasting haematuria, a higher perception of pain, and a more negative impact on quality of life compared to patients undergoing TULA. TURBT-treated patients had more cases of acute urinary retention and a higher need for contacting the healthcare system. Side effects following transurethral procedures were common but generally not severe. The early symptom burden following TURBT was more extensive than that following TULA.
膀胱肿瘤诊断与治疗的标准术式——经尿道膀胱肿瘤切除术（TURBT）并发症发生率高达26%，可能对患者报告结局（PRO）产生显著影响。门诊经尿道激光消融术（TULA）作为一种新兴微创治疗方式，具有更低的并发症风险，可能改善患者报告结局。本研究通过收集膀胱肿瘤经尿道手术后的患者报告结局，评估症状与副作用的临床差异。这项前瞻性观察研究连续纳入接受不同经尿道膀胱肿瘤手术的患者，分别在术后第1天和第14天填写尿路症状量表（ICIQ-LUTS）、术后副作用调查表及生活质量量表（EQ-5D-3L）。共108例患者参与研究，最常见的术后表现为血尿和疼痛。与接受TULA治疗的患者相比，接受TURBT治疗的患者血尿持续时间更长、疼痛感知更明显、对生活质量的负面影响更显著。TURBT治疗组急性尿潴留发生率更高，且更频繁需要联系医疗系统。经尿道手术后的副作用较为常见但总体不严重，TURBT术后的早期症状负担较TULA更为广泛。
肿瘤(癌症)患者之家