Painful pelvic and spinal bone metastases are a considerable challenge for doctors and patients. Conventional therapies include morphine-equivalent medication (MeM) and local radiotherapy (RT), but these interventions are not always successful. More recently, hyperthermia (HT) has been applied to complement RT and MeM, and this complex approach has shown promising synergistic results. The objective of our study was to present the results of RT combined with a special kind of HT (modulated electrohyperthermia, mEHT), in which some of the thermal effect is contributed by equivalent nonthermal components, drastically reducing the necessary power and energy. This retrospective study included 61 patients divided into three groups with pelvic and spinal bone metastases to compare the effects of RT and mEHT alone and in combination (RT + mEHT). A detailed evaluation of pain intensity, measured by the brief pain inventory score, MeM use, and breakthrough pain episodes, revealed no significant differences between RT and mEHT alone; thus, these individual methods were considered equivalent. However, RT + mEHT yielded significantly better results in terms of the above parameters. Clinically, mEHT has a lower risk of adverse thermal effects, and due to its efficacy, mEHT can be used to treat RT-resistant lesions.
疼痛性盆腔及脊柱骨转移对医患双方均构成重大挑战。传统治疗方案包括吗啡等效药物（MeM）与局部放射治疗（RT），但这些干预措施并非总能取得理想疗效。近年来，热疗（HT）被应用于辅助RT与MeM，这种复合疗法已展现出具有前景的协同效应。本研究旨在探讨RT联合特殊类型HT（调幅电热疗，mEHT）的治疗效果，该技术通过等效非热效应成分实现部分热效应，从而显著降低所需功率与能量。本回顾性研究纳入61例盆腔及脊柱骨转移患者，分为三组以比较单纯RT、单纯mEHT及联合治疗（RT+mEHT）的疗效。通过简明疼痛量表评分、MeM使用情况及爆发痛发作次数对疼痛强度进行详细评估，结果显示单纯RT与单纯mEHT组间无显著差异，表明两种单一疗法效果相当。然而，RT+mEHT联合治疗在以上参数方面均呈现显著更优的临床结果。从临床角度看，mEHT具有较低的热相关不良反应风险，且因其显著疗效，可用于治疗放射抵抗性病灶。
肿瘤(癌症)患者之家