文章：

I型干扰素在免疫细胞中的信号传导：疾病后果

Signaling by Type I Interferons in Immune Cells: Disease Consequences

原文发布日期：22 April 2024

DOI: 10.3390/cancers16081600

类型: Article

开放获取: 是

英文摘要：

This review addresses interferon (IFN) signaling in immune cells and the tumor microenvironment (TME) and examines how this affects cancer progression. The data reveal that IFNs exert dual roles in cancers, dependent on the TME, exhibiting both anti-tumor activity and promoting cancer progression. We discuss the abnormal IFN signaling induced by cancerous cells that alters immune responses to permit their survival and proliferation.

摘要翻译： 

本综述探讨了免疫细胞及肿瘤微环境中的干扰素信号传导，并分析了其对癌症进展的影响。数据显示，干扰素在癌症中发挥双重作用，其具体效应取决于肿瘤微环境，既可表现出抗肿瘤活性，亦能促进癌症进展。文中讨论了癌细胞诱导的异常干扰素信号如何改变免疫应答，从而为癌细胞的存活与增殖创造条件。

原文链接：

Signaling by Type I Interferons in Immune Cells: Disease Consequences