Purpose: The study aims to examine the possible correlation between genomic alterations and preoperative olfactory function in patients with olfactory groove meningioma (OGM), due to the frequent presence of olfactory impairment. Methods: We utilised next-generation sequencing to analyse samples from 22 individuals with OGM in order to detect driver mutations. Tumour morphology was assessed using preoperative imaging, whereas olfactory function was examined using Sniffin’ Sticks. Results: In a study of 22 OGM patients, mutations were as follows: 10 withSMO/SUFU, 7 withAKT1, and 5 as wild type. Planum sphenoidale hyperostosis (PSH) was present in 75% of patients, showing significant variation by mutation (p= 0.048). Tumour volumes, averaging 25 cm3, significantly differed among groups. PSH negatively impacted olfaction, notably affecting odour threshold, discrimination, identification, and global olfactory performance score (TDI) (pvalues ranging from <0.001 to 0.003). Perifocal oedema was associated with lower TDI (p= 0.009) and altered threshold scores (p= 0.038). Age over 65 and female gender were linked to lower thresholds and discrimination scores (p= 0.037 andp= 0.019). Conclusion: The study highlights PSH and perifocal oedema’s significant effect on olfactory function in OGM patients but finds no link between olfactory impairment and tumour mutations, possibly due to the small sample size. This suggests that age and gender affect olfactory impairment. Additional research with a larger group of participants is needed to explore the impact of OGM driver mutations on olfactory performance.
目的：鉴于嗅觉功能障碍在嗅沟脑膜瘤患者中普遍存在，本研究旨在探讨基因组改变与术前嗅觉功能之间可能存在的关联。方法：我们采用新一代测序技术对22例嗅沟脑膜瘤患者的样本进行分析，以检测驱动基因突变。通过术前影像学评估肿瘤形态，并采用Sniffin’ Sticks嗅觉测试评估嗅觉功能。结果：在22例嗅沟脑膜瘤患者中，基因突变分布如下：10例携带SMO/SUFU突变，7例携带AKT1突变，5例为野生型。75%的患者存在蝶骨平台骨质增生，且不同突变类型间该特征存在显著差异（p=0.048）。各组间平均体积为25 cm³的肿瘤体积存在显著差异。蝶骨平台骨质增生对嗅觉功能产生负面影响，显著降低气味阈值、辨别力、识别能力及整体嗅觉表现评分（p值范围<0.001至0.003）。瘤周水肿与较低的嗅觉总分（p=0.009）及改变的阈值评分相关（p=0.038）。年龄超过65岁及女性性别与较低的阈值和辨别力评分相关（p=0.037和p=0.019）。结论：本研究强调了蝶骨平台骨质增生和瘤周水肿对嗅沟脑膜瘤患者嗅觉功能的显著影响，但未发现嗅觉障碍与肿瘤基因突变间的关联，这可能受限于样本量较小。研究提示年龄和性别因素会影响嗅觉功能障碍。未来需要更大样本量的研究进一步探讨嗅沟脑膜瘤驱动基因突变对嗅觉功能的影响。
Correlation of Molecular Status with Preoperative Olfactory Function in Olfactory Groove Meningioma
肿瘤(癌症)患者之家