Theranostics define diagnostic evaluations directing patient-specific therapeutic decisions. Molecular theranostics involves genomic, transcriptomic, proteomic, metabolomic and finally phenonic definitions thyroid cancer differentiation. It is the functional differentiation that determines the sensitivity and accuracy of RAI imaging as well as the effectiveness of RAI treatment. Total thyroidectomy is performed to empower an anticipated RAI treatment. A preoperative determination of the genomic and transcriptomic profile of the tumor is a strong predictor of response to therapeutic interventions. This article discusses the oncopathophysiologic basis of the theranostic risk stratification approach.
诊疗学旨在通过诊断评估指导个体化治疗决策。分子诊疗学涵盖甲状腺癌分化的基因组学、转录组学、蛋白质组学、代谢组学及最终表型组学定义。功能分化程度直接决定放射性碘成像的敏感性与精确度，并影响放射性碘治疗效果。全甲状腺切除术的实施旨在为预期放射性碘治疗创造条件。术前对肿瘤基因组和转录组特征的测定，是预测治疗干预反应的重要指标。本文系统探讨诊疗学风险分层方法的肿瘤病理生理学基础。
Theranostic Risk Stratification for Thyroid Cancer in the Genomic Paradigm
肿瘤(癌症)患者之家