Given the importance of maximizing resection for prognosis in patients with HGG and the potential risks associated with ventricle opening, this study aimed to assess the actual increase in post-surgical complications related to lateral ventricle opening and its influence on OS and PFS. A retrospective study was conducted on newly diagnosed HGG, dividing the patients into two groups according to whether the lateral ventricle was opened (69 patients) or not opened (311 patients). PFS, OS, subependymal dissemination, distant parenchymal recurrences, the development of hydrocephalus and CSF leak were considered outcome measures. A cohort of 380 patients (154 females (40.5%) and 226 males (59.5%)) was involved in the study (median age 61 years). The PFS averaged 10.9 months (±13.3 SD), and OS averaged 16.6 months (± 16.3 SD). Among complications, subependymal dissemination was registered in 15 cases (3.9%), multifocal and multicentric progression in 56 cases (14.7%), leptomeningeal dissemination in 12 (3.2%) and hydrocephalus in 8 (2.1%). These occurrences could not be clearly justified by ventricular opening. The act of opening the lateral ventricles itself does not carry an elevated risk of dissemination, hydrocephalus or cerebrospinal fluid (CSF) leak. Therefore, if necessary, it should be pursued to achieve radical removal of the disease.
鉴于最大程度切除对高级别胶质瘤（HGG）患者预后的重要性，以及开放脑室可能带来的潜在风险，本研究旨在评估开放侧脑室相关术后并发症的实际增加情况及其对总生存期（OS）和无进展生存期（PFS）的影响。本研究对新诊断的HGG患者进行了回顾性分析，根据是否开放侧脑室将患者分为两组：开放组（69例）和未开放组（311例）。研究将PFS、OS、室管膜下播散、远处脑实质复发、脑积水的发生及脑脊液漏作为结局指标。研究共纳入380例患者，其中女性154例（40.5%），男性226例（59.5%），中位年龄61岁。平均PFS为10.9个月（±13.3标准差），平均OS为16.6个月（±16.3标准差）。并发症方面，室管膜下播散15例（3.9%），多灶性及多中心进展56例（14.7%），软脑膜播散12例（3.2%），脑积水8例（2.1%）。这些情况的发生均无法明确归因于脑室开放。开放侧脑室这一操作本身并未增加肿瘤播散、脑积水或脑脊液漏的风险。因此，若为实现疾病的根治性切除所需，应积极进行该操作。
肿瘤(癌症)患者之家