High-grade serous ovarian cancer (HGSOC) is the predominant subtype of ovarian cancer (OC), occurring in more than 80% of patients diagnosed with this malignancy. Histological and genetic analysis have confirmed the secretory epithelial of the fallopian tube (FT) as a major site of origin of HGSOC. Although there have been significant strides in our understanding of this disease, early stage detection and diagnosis are still rare. Current clinical imaging modalities lack the ability to detect early stage pathogenesis in the fallopian tubes and the ovaries. However, there are several microscopic imaging techniques used to analyze the structural modifications in the extracellular matrix (ECM) protein collagen in ex vivo FT and ovarian tissues that potentially can be modified to fit the clinical setting. In this perspective, we evaluate and compare the myriad of optical tools available to visualize these alterations and the invaluable insights these data provide on HGSOC initiation. We also discuss the clinical implications of these findings and how these data may help novel tools for early diagnosis of HGSOC.
高级别浆液性卵巢癌（HGSOC）是卵巢癌（OC）的主要亚型，在确诊为该恶性肿瘤的患者中占比超过80%。组织学和遗传学分析已证实输卵管（FT）的分泌上皮是HGSOC的主要起源部位。尽管对该疾病的认识已取得显著进展，但早期检测与诊断仍属罕见。目前临床影像学方法尚无法检测输卵管和卵巢的早期病理变化。然而，现有多种显微成像技术可用于分析离体输卵管及卵巢组织中细胞外基质（ECM）蛋白胶原的结构改变，这些技术经改良后有望应用于临床环境。本文评估并比较了多种可用于观察这些结构改变的光学工具，以及这些数据为揭示HGSOC发生机制提供的宝贵见解。同时探讨了这些发现的临床意义，以及如何利用这些数据开发新型HGSOC早期诊断工具。
肿瘤(癌症)患者之家