Cancer is a life-threatening disease and one of the leading causes of death worldwide. Despite significant advancements in therapeutic options, most available anti-cancer agents have limited efficacy. In this context, natural compounds with diverse chemical structures have been investigated for their multimodal anti-cancer properties. Curcumin is a polyphenol isolated from the rhizomes ofCurcuma longaand has been widely studied for its anti-inflammatory, anti-oxidant, and anti-cancer effects. Curcumin acts on the regulation of different aspects of cancer development, including initiation, metastasis, angiogenesis, and progression. The phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT) pathway is a key target in cancer therapy, since it is implicated in initiation, proliferation, and cancer cell survival. Curcumin has been found to inhibit the PI3K/Akt pathway in tumor cells, primarily via the regulation of different key mediators, including growth factors, protein kinases, and cytokines. This review presents the therapeutic potential of curcumin in different malignancies, such as glioblastoma, prostate and breast cancer, and head and neck cancers, through the targeting of the PI3K/Akt signaling pathway.
癌症是一种危及生命的疾病，也是全球主要死亡原因之一。尽管治疗手段已取得显著进展，但现有大多数抗癌药物的疗效仍存在局限。在此背景下，具有多样化化学结构的天然化合物因其多模式抗癌特性而受到广泛研究。姜黄素是从姜黄根茎中分离出的多酚类物质，其抗炎、抗氧化及抗癌作用已被广泛证实。该化合物通过调控癌症发生、转移、血管生成及进展等多个环节发挥抗癌作用。磷脂酰肌醇-3-激酶（PI3K）/蛋白激酶B（AKT）信号通路作为癌症治疗的关键靶点，在肿瘤发生、增殖及癌细胞存活中发挥重要作用。研究发现姜黄素主要通过调控生长因子、蛋白激酶和细胞因子等关键介质，抑制肿瘤细胞中的PI3K/Akt通路。本综述通过探讨姜黄素靶向PI3K/Akt信号通路的作用机制，系统阐述其在胶质母细胞瘤、前列腺癌、乳腺癌及头颈癌等多种恶性肿瘤中的治疗潜力。
The Role of Curcumin in Cancer: A Focus on the PI3K/Akt Pathway
肿瘤(癌症)患者之家