Some researchers have speculated that the prostatic microbiome is involved in the development of prostate cancer (PCa) but there is no consensus on certain microbiota in the prostatic tissue of PCa vs. healthy controls. This systematic review aims to investigate and compare the microbiome of PCa and healthy tissue to determine the microbial association with the pathogenesis of PCa. We searched MEDLINE, Embase, and Scopus databases. Articles were screened by two independent and blinded reviewers. Literature that compared the prostatic tissue microbiome of patients with PCa with benign controls was included. We found that PCa may be associated with increasedPropionibacterium acnes, the herpesviridae andpapillomaviridaefamilies, andMycoplasma genitalium, but definitive conclusions cannot be drawn from the existing data. Challenges include the difficulty of obtaining uncontaminated tissue samples and securing tissue from healthy controls. As a result, methods are varied with many studies using cancerous and “healthy” tissue from the same prostate. The organisms chosen for each study were also highly variable, making it difficult to compare studies. These issues have led to lower confidence in our results. Overall, further work is warranted to better understand the implications of the prostatic microbiome in the pathogenesis of PCa.
部分研究者推测前列腺微生物组与前列腺癌（PCa）的发生发展相关，但关于PCa患者与健康对照者前列腺组织中特定微生物群是否存在差异尚未达成共识。本系统综述旨在探究并比较PCa组织与健康组织的微生物组，以明确微生物群与PCa发病机制的关联。我们检索了MEDLINE、Embase和Scopus数据库，由两名独立盲审员进行文献筛选，纳入比较PCa患者与良性对照者前列腺组织微生物组的研究。研究发现PCa可能与痤疮丙酸杆菌、疱疹病毒科、乳头瘤病毒科及生殖支原体的丰度增加相关，但现有数据尚不能得出确定性结论。研究面临的挑战包括难以获取无污染的组织样本及健康对照组织，导致研究方法存在差异——许多研究使用同一前列腺的癌变组织与"健康"组织进行对比。各研究选择的检测微生物也存在高度异质性，使得研究间难以直接比较。这些问题导致我们对研究结果的置信度降低。总体而言，需要进一步研究以更好地理解前列腺微生物组在PCa发病机制中的作用。
Prostate Tissue Microbiome in Patients with Prostate Cancer: A Systematic Review
肿瘤(癌症)患者之家