Children undergoing antineoplastic treatment often present severe side effects due to the dosage and duration of treatments, with oral mucositis emerging as one of the most prevalent and painful inflammatory conditions. There is a growing body of evidence on therapeutic interventions such as cryotherapy, low-level laser therapy, and natural compounds for this condition. The aim of this systematic review was to identify and compare therapies for the management of cancer treatment-induced oral mucositis in pediatric patients. From 2655 articles obtained in initial searches, 39 articles were considered in this systematic review, after applying inclusion/exclusion criteria. Low-level laser therapy, palifermin, honey, and zinc demonstrated reductions in oral mucositis incidence, duration, severity, and pain reported by the patient. Although there are several therapies in place for the prevention and treatment of oral mucositis in children, evidence of their efficacy is still inconclusive to establish accurate clinical protocols.
接受抗肿瘤治疗的儿童常因治疗剂量与时长出现严重副作用，其中口腔黏膜炎已成为最常见且痛苦的炎症反应之一。目前关于冷冻疗法、低强度激光治疗及天然化合物等干预措施的研究证据日益增多。本系统综述旨在识别并比较针对儿童癌症治疗相关口腔黏膜炎的临床干预方案。通过初步检索获得2655篇文献，经纳入/排除标准筛选后，最终纳入39篇文献进行系统分析。低强度激光疗法、帕利夫明、蜂蜜及锌制剂等干预措施在降低口腔黏膜炎发生率、缩短持续时间、减轻严重程度及缓解患者疼痛方面显示出积极效果。尽管目前存在多种针对儿童口腔黏膜炎的防治方案，但其疗效证据尚不足以支撑建立精确的临床治疗规范。
Oral Mucositis Management in Children under Cancer Treatment: A Systematic Review
肿瘤(癌症)患者之家